Background: No recent national-level data on the aetiology of chronic hepatitis are available in Italy. Aim: To evaluate the current aetiology of chronic hepatitis in Italy. Patients: A total of 6210 chronic hepatitis patients (both prevalence and incident cases) consecutively admitted to 79 hospitals located throughout Italy were enrolled over a 6-month period in 2001. The hospitals were randomly selected through systematic cluster sampling. Results: The main agent associated with chronic hepatitis was hepatitis C virus, which was found in 76.5% of the patients (in 62.6% it was the only aetiologic factor). Hepatitis B surface antigen was present in the serum of 12.2% of the cases (in 9.2% it was the only aetiologic factor). Hepatitis B e antigen and hepatitis Delta were detected in 16.6% and 7.0%, respectively, of hepatitis B surface antigen-positive patients. A history of alcohol abuse was found in 19.2% of the cases (5.5% without viral infection). Autoimmune hepatitis and inborn metabolic disorders were extremely rare. The prevalence of hepatitis C virus-related cases was significantly lower in incident cases, compared to prevalent cases (55.1% versus 65.0%; p < 0.01). The mean alanine aminotransferase level was significantly higher in hepatitis B surface antigen-positive patients, compared to hepatitis B surface antigen-negative patients. The histology was less severe in non-viral-related cases. Conclusions: Hepatitis C virus is the most important pathogenic factor for chronic hepatitis in Italy; however, the comparison between prevalent and incident cases suggests that this infection will play a less important role in the future. A comparison with previous reports shows that both hepatitis B virus-related and hepatitis Delta virus-related cases are decreasing. © 2004 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.

The aetiology of chronic hepatitis in Italy: Results from a multicentre national study

Oriolo, M.;Capra, F.;Sama, C.;Boccia, S.;Praticò, A.;Ventura, E.;Solinas, A.;Clementi, C.;Festi, D.;Borgia, G.;Coppola, C.;ELIA, ANTONIO;
2004

Abstract

Background: No recent national-level data on the aetiology of chronic hepatitis are available in Italy. Aim: To evaluate the current aetiology of chronic hepatitis in Italy. Patients: A total of 6210 chronic hepatitis patients (both prevalence and incident cases) consecutively admitted to 79 hospitals located throughout Italy were enrolled over a 6-month period in 2001. The hospitals were randomly selected through systematic cluster sampling. Results: The main agent associated with chronic hepatitis was hepatitis C virus, which was found in 76.5% of the patients (in 62.6% it was the only aetiologic factor). Hepatitis B surface antigen was present in the serum of 12.2% of the cases (in 9.2% it was the only aetiologic factor). Hepatitis B e antigen and hepatitis Delta were detected in 16.6% and 7.0%, respectively, of hepatitis B surface antigen-positive patients. A history of alcohol abuse was found in 19.2% of the cases (5.5% without viral infection). Autoimmune hepatitis and inborn metabolic disorders were extremely rare. The prevalence of hepatitis C virus-related cases was significantly lower in incident cases, compared to prevalent cases (55.1% versus 65.0%; p < 0.01). The mean alanine aminotransferase level was significantly higher in hepatitis B surface antigen-positive patients, compared to hepatitis B surface antigen-negative patients. The histology was less severe in non-viral-related cases. Conclusions: Hepatitis C virus is the most important pathogenic factor for chronic hepatitis in Italy; however, the comparison between prevalent and incident cases suggests that this infection will play a less important role in the future. A comparison with previous reports shows that both hepatitis B virus-related and hepatitis Delta virus-related cases are decreasing. © 2004 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.
Stroffolini, T.; Sagnelli, E.; Mele, A.; Craxì, A.; Almasio, P.; Traverso, A.; Arrigoni, A.; Torchio, M.; Garbagnoli, P.; Del Mastro, B.; Romano, P.; Vanni, R.; Brusita, D.; Meucci, P.; Cassola, G.; Borzio, M.; Bellobuono, A.; De Bona, A.; Re, T.; Del Poggio, P.; Baisini, O.; Colombo, A.; Attolini, C.; Daria, S.; Minoli, L.; Gazzaniga, V.; Segato, S.; Oriolo, M.; Parlotto, A.; Ghersetti, M.; Capra, F.; Muratori, R.; Sama, C.; Boccia, S.; Verdianelli, G.; Praticò, A.; Grandi, M.; Ventura, E.; Cantoni, F.; Vincenti, A.; Nerli Alessandro, A.; Galeazzi, L.; Solinas, A.; Paroli, M.; De Sanctis, G.M.; Sereno, S.; Clementi, C.; Visco Comandino, U.; Gallo, A.I.; Festi, D.; Sabusco, G.; Coppola, N.; Scolastico, C.; Onofrio, M.; Imparato, M.; Filippini, P.; Morisco, F.; Liberti, A.; Borgia, G.; Scarpellino, F.; Persico, M.; Sagnelli, C.; Coppola, C.; Caserta, L.; Elia, A.; De Vita, G.; Lanzotti, A.; Pizzolante, L.; Messina, V.; Fiore, G.; Agostinacchio, E.; Santantonio, T.; Mazzola, M.; Vinelli, F.; Campagna, A.; Cataldini, S.; Monelli, I.; Lascaro, M.; Polimeri, N.; Frigiuele, P.; Ferraro, M.; Prestileo, T.; Alessandri, A.; Russello Maurizio, M.; Bellissima, P.; Orifici, G.; Pisani, G.; Angioini, S.; Lai, M.; Spanneda, M.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11585/631990
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