Remarkable generality in scope of new C9-benzoylcupreines bearing electron-withdrawing substituents for the nitroaldol condensation with fluoromethyl ketones is presented. Both triand difluoromethyl ketones provided excellent levels of stereoinduction (ee 76–99%) under mild reaction conditions and low loading of catalyst (1–5 mol%).
Titolo: | Enantioselective organocatalyzed Henry reaction with fluoromethyl ketone | |
Autore/i: | BANDINI, MARCO; SINISI, RICCARDO; UMANI RONCHI, ACHILLE | |
Autore/i Unibo: | ||
Anno: | 2008 | |
Rivista: | ||
Digital Object Identifier (DOI): | http://dx.doi.org/10.1039/b807640e | |
Abstract: | Remarkable generality in scope of new C9-benzoylcupreines bearing electron-withdrawing substituents for the nitroaldol condensation with fluoromethyl ketones is presented. Both triand difluoromethyl ketones provided excellent levels of stereoinduction (ee 76–99%) under mild reaction conditions and low loading of catalyst (1–5 mol%). | |
Data prodotto definitivo in UGOV: | 2008-10-22 14:36:02 | |
Appare nelle tipologie: | 1.01 Articolo in rivista |
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