Remarkable generality in scope of new C9-benzoylcupreines bearing electron-withdrawing substituents for the nitroaldol condensation with fluoromethyl ketones is presented. Both triand difluoromethyl ketones provided excellent levels of stereoinduction (ee 76–99%) under mild reaction conditions and low loading of catalyst (1–5 mol%).
M. Bandini, R. Sinisi, A. Umani-Ronchi (2008). Enantioselective organocatalyzed Henry reaction with fluoromethyl ketone. CHEMICAL COMMUNICATIONS, --, 4360-4362 [10.1039/b807640e].
Enantioselective organocatalyzed Henry reaction with fluoromethyl ketone
BANDINI, MARCO;SINISI, RICCARDO;UMANI RONCHI, ACHILLE
2008
Abstract
Remarkable generality in scope of new C9-benzoylcupreines bearing electron-withdrawing substituents for the nitroaldol condensation with fluoromethyl ketones is presented. Both triand difluoromethyl ketones provided excellent levels of stereoinduction (ee 76–99%) under mild reaction conditions and low loading of catalyst (1–5 mol%).File in questo prodotto:
Eventuali allegati, non sono esposti
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
