Remarkable generality in scope of new C9-benzoylcupreines bearing electron-withdrawing substituents for the nitroaldol condensation with fluoromethyl ketones is presented. Both triand difluoromethyl ketones provided excellent levels of stereoinduction (ee 76–99%) under mild reaction conditions and low loading of catalyst (1–5 mol%).

Enantioselective organocatalyzed Henry reaction with fluoromethyl ketone

BANDINI, MARCO;SINISI, RICCARDO;UMANI RONCHI, ACHILLE
2008

Abstract

Remarkable generality in scope of new C9-benzoylcupreines bearing electron-withdrawing substituents for the nitroaldol condensation with fluoromethyl ketones is presented. Both triand difluoromethyl ketones provided excellent levels of stereoinduction (ee 76–99%) under mild reaction conditions and low loading of catalyst (1–5 mol%).
M. Bandini; R. Sinisi; A. Umani-Ronchi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/63027
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