138 BN O Sclerostin as a marker of bone remodeling induced by high impact activity A Cicchella1, J. Jurimae2, V. Tillmann2, L. Rizzo1, C. Stefanelli1, M. Zini1, K. Vosoberg2, A. L. Tamm2, T. Jurimae2 1University of Bologna, Department for Quality of Life Studies, Italy; 2Tartu University, Faculty of Medicine, Institute of Sport Sciences and Physiotherapy, Estonia Aims: Rhythmic gymnasts RG has a beneficial effect on bone mineralization (Ju¨rima¨e et al. 2016), despite higher levels of circulating sclerostin. In the present follow up study, we observed at 9 months if there was an effect of RG load on maturity, bone health, and if the levels of sclerostin, leptin and adiponectin were influenced by growth and training. Methods: We measured sclerostin, leptin and adiponectin together with body mass parameters and bone mineral content in the same groups (RG = 31 and untrained controls UC = 21) 9 months later. Results: In the control group 15 on 21 subjects (71 %) entered Tanner Stage II, in RG groups 28 on 31 (90 %). Whole body mineral density and content, mineral density at lumbar spine and femoral neck and sclerostin increased at follow-up in both groups. Sclerostin increase was dramatic for RG group and of less extent for the UC group. Leptin levels decreased for the RG group and increased for the UC group, according to fat mass increase. Adiponectin remained stable for RG group and decreased for UC group. Conclusions: In RG group, Leptin decreased, Leptin increased in the UC controls. Adiponectin remain stable in RG group and decrease in UC. Sclerostin increased in RG and UC according to increase in bone mass content. In RG, sclerostin increase was higher. We can conclude RG training has a beneficial effect on bone turnover and that sclerostin can be considered as marker of bone turnover not connected with lack of bone osteogenesis in populations participating in high impact physical activities. Reference Ju¨rima¨e J, Tillmann V, Cicchella A, Stefanelli C, Vo˜soberg K, Tamm AL, Ju¨rima¨e T (2016) Increased sclerostin and preadipocyte factor-1 levels in prepubertal rhythmic gymnasts: associations with bone mineral density, body composition, and adipocytokine values. Osteoporos Int 27:1239–1243.

Sclerostin as a marker of bone remodeling induced by high impact activity

CICCHELLA A.;RIZZO, LUNA;STEFANELLI, CLAUDIO;ZINI, MADDALENA;
2016

Abstract

138 BN O Sclerostin as a marker of bone remodeling induced by high impact activity A Cicchella1, J. Jurimae2, V. Tillmann2, L. Rizzo1, C. Stefanelli1, M. Zini1, K. Vosoberg2, A. L. Tamm2, T. Jurimae2 1University of Bologna, Department for Quality of Life Studies, Italy; 2Tartu University, Faculty of Medicine, Institute of Sport Sciences and Physiotherapy, Estonia Aims: Rhythmic gymnasts RG has a beneficial effect on bone mineralization (Ju¨rima¨e et al. 2016), despite higher levels of circulating sclerostin. In the present follow up study, we observed at 9 months if there was an effect of RG load on maturity, bone health, and if the levels of sclerostin, leptin and adiponectin were influenced by growth and training. Methods: We measured sclerostin, leptin and adiponectin together with body mass parameters and bone mineral content in the same groups (RG = 31 and untrained controls UC = 21) 9 months later. Results: In the control group 15 on 21 subjects (71 %) entered Tanner Stage II, in RG groups 28 on 31 (90 %). Whole body mineral density and content, mineral density at lumbar spine and femoral neck and sclerostin increased at follow-up in both groups. Sclerostin increase was dramatic for RG group and of less extent for the UC group. Leptin levels decreased for the RG group and increased for the UC group, according to fat mass increase. Adiponectin remained stable for RG group and decreased for UC group. Conclusions: In RG group, Leptin decreased, Leptin increased in the UC controls. Adiponectin remain stable in RG group and decrease in UC. Sclerostin increased in RG and UC according to increase in bone mass content. In RG, sclerostin increase was higher. We can conclude RG training has a beneficial effect on bone turnover and that sclerostin can be considered as marker of bone turnover not connected with lack of bone osteogenesis in populations participating in high impact physical activities. Reference Ju¨rima¨e J, Tillmann V, Cicchella A, Stefanelli C, Vo˜soberg K, Tamm AL, Ju¨rima¨e T (2016) Increased sclerostin and preadipocyte factor-1 levels in prepubertal rhythmic gymnasts: associations with bone mineral density, body composition, and adipocytokine values. Osteoporos Int 27:1239–1243.
CICCHELLA A.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11585/629457
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