Context. In the last decades, the attention to Intraductal Papillary Mucinous Neoplasms (IPMNs) has raised due to the increase of their incidental diagnosis. Objective. The aim of our study was to evaluate which factors influenced survival in our population affected by IPMN. Methods. A retrospective study on a prospective da- tabase of 357 patients observed at our institution from January 2004 until January 2016 was conducted. Pre-, intra- and postoperative data were collected. Patients managed conservatively were compared with those who underwent surgery as regards demographic, clini- cal data, radiological work up, features of the cysts and overall survival (OS). Multivariate analyses were carried out in order to assess factors related to patients’ man- agement as well as those related to OS. Results. Multivariate analysis showed that the factors strongly related to surgery were: location in the tail of the pancreas (OR 4.48; P=0.011), presence of mu- ral nodules (OR 15.39; P<0.001), Wirsung size > 5 mm (OR 8.55; P<0.001), Wirsung size ≥ 10mm (OR 133.75; P<0.001), a positive citology (OR 19.81; P=0.008) and acute pancreatitis (OR 16.7; P<0.001); conversely, age was independently related to the follow-up strategy (OR 0.93; P=0.001). Furthermore, parameters that significantly influenced OS were: age (HR 1.07; P<0.001), jaundice (HR 7.67; P<0.001) and the presence of mural nodules (HR 2.03; P=0.019). Conclusions. Despite the limitations of the study, the main factors related to OS in our experience were age- ing, jaundice and the presence of mural nodules within the cyst.

Giovanni Taffurelli, C.R. (2017). Intraductal papillary mucinous neoplasms: the bologna experience. Lessons learned from 357 cases observed in a tertiary care center. MINERVA GASTROENTEROLOGICA E DIETOLOGICA, 63(Suppl. I N° 4), 16-17.

Intraductal papillary mucinous neoplasms: the bologna experience. Lessons learned from 357 cases observed in a tertiary care center

Giovanni Taffurelli
Writing – Original Draft Preparation
;
Claudio Ricci
Writing – Review & Editing
;
Carlo Alberto Pacilio
Membro del Collaboration Group
;
Nico Pagano
Membro del Collaboration Group
;
Donatella Santini
Membro del Collaboration Group
;
Marina Migliori
Membro del Collaboration Group
;
Mariacristina Di Marco
Membro del Collaboration Group
;
Carla Serra
Membro del Collaboration Group
;
Lucia Calculli
Membro del Collaboration Group
;
Roberto De Giorgio
Membro del Collaboration Group
;
Francesco Minni
Supervision
;
Riccardo Casadei
Project Administration
2017

Abstract

Context. In the last decades, the attention to Intraductal Papillary Mucinous Neoplasms (IPMNs) has raised due to the increase of their incidental diagnosis. Objective. The aim of our study was to evaluate which factors influenced survival in our population affected by IPMN. Methods. A retrospective study on a prospective da- tabase of 357 patients observed at our institution from January 2004 until January 2016 was conducted. Pre-, intra- and postoperative data were collected. Patients managed conservatively were compared with those who underwent surgery as regards demographic, clini- cal data, radiological work up, features of the cysts and overall survival (OS). Multivariate analyses were carried out in order to assess factors related to patients’ man- agement as well as those related to OS. Results. Multivariate analysis showed that the factors strongly related to surgery were: location in the tail of the pancreas (OR 4.48; P=0.011), presence of mu- ral nodules (OR 15.39; P<0.001), Wirsung size > 5 mm (OR 8.55; P<0.001), Wirsung size ≥ 10mm (OR 133.75; P<0.001), a positive citology (OR 19.81; P=0.008) and acute pancreatitis (OR 16.7; P<0.001); conversely, age was independently related to the follow-up strategy (OR 0.93; P=0.001). Furthermore, parameters that significantly influenced OS were: age (HR 1.07; P<0.001), jaundice (HR 7.67; P<0.001) and the presence of mural nodules (HR 2.03; P=0.019). Conclusions. Despite the limitations of the study, the main factors related to OS in our experience were age- ing, jaundice and the presence of mural nodules within the cyst.
2017
Giovanni Taffurelli, C.R. (2017). Intraductal papillary mucinous neoplasms: the bologna experience. Lessons learned from 357 cases observed in a tertiary care center. MINERVA GASTROENTEROLOGICA E DIETOLOGICA, 63(Suppl. I N° 4), 16-17.
Giovanni Taffurelli, Claudio Ricci, Carlo Alberto Pacilio, Nico Pagano, Donatella Santini , Marina Migliori, Mariacristina Di Marco, Carla Serra, Luci...espandi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/628738
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