Background: Growth hormone (GH) influences glucose homeostasis by negatively affecting insulin sensitivity, leading to a compensatory increase in insulin secretion. It has recently been reported, in animals and humans, that GH might also stimulate insulin secretion by directly affecting the growth and function of pancreatic β-cells. The aim of this work was to longitudinally study the insulin sensitivity (HOMA-S), insulin secretion [insulinogenic index (IGI)] and capacity of β-cells to adapt to changes in insulin sensitivity [oral disposition index (ODI)] in GH-deficient (GHD) children under GH treatment. Methods: We studied 99 GHD (62 male, 37 female; age 8.9 ± 3.5 years) children for a median period of 6 years (range 1.5-16.2). Every year, our patients underwent an oral glucose tolerance test, which was used to calculate the HOMA-S, IGI and ODI. Results: Although HOMA-S remained unchanged, an increase in IGI and ODI was observed, becoming significant after 6 years of treatment (1.25 ± 1.28 vs. 2.35 ± 2.38, p < 0.05 and 0.57 ± 0.68 vs. 1.50 ± 1.92, p < 0.01, respectively). Conclusion: Our results suggest a positive influence of GH treatment on the β-cell secretory capacity in children with GH deficiency.

Baronio, F., Mazzanti, L., Girtler, Y., Tamburrino, F., Fazzi, A., Lupi, F., et al. (2016). The influence of growth hormone treatment on glucose homeostasis in growthhormone-deficient children: A six-year follow-up study. HORMONE RESEARCH IN PAEDIATRICS, 86(3), 196-200 [10.1159/000448841].

The influence of growth hormone treatment on glucose homeostasis in growthhormone-deficient children: A six-year follow-up study

Mazzanti, Laura
Investigation
;
2016

Abstract

Background: Growth hormone (GH) influences glucose homeostasis by negatively affecting insulin sensitivity, leading to a compensatory increase in insulin secretion. It has recently been reported, in animals and humans, that GH might also stimulate insulin secretion by directly affecting the growth and function of pancreatic β-cells. The aim of this work was to longitudinally study the insulin sensitivity (HOMA-S), insulin secretion [insulinogenic index (IGI)] and capacity of β-cells to adapt to changes in insulin sensitivity [oral disposition index (ODI)] in GH-deficient (GHD) children under GH treatment. Methods: We studied 99 GHD (62 male, 37 female; age 8.9 ± 3.5 years) children for a median period of 6 years (range 1.5-16.2). Every year, our patients underwent an oral glucose tolerance test, which was used to calculate the HOMA-S, IGI and ODI. Results: Although HOMA-S remained unchanged, an increase in IGI and ODI was observed, becoming significant after 6 years of treatment (1.25 ± 1.28 vs. 2.35 ± 2.38, p < 0.05 and 0.57 ± 0.68 vs. 1.50 ± 1.92, p < 0.01, respectively). Conclusion: Our results suggest a positive influence of GH treatment on the β-cell secretory capacity in children with GH deficiency.
2016
Baronio, F., Mazzanti, L., Girtler, Y., Tamburrino, F., Fazzi, A., Lupi, F., et al. (2016). The influence of growth hormone treatment on glucose homeostasis in growthhormone-deficient children: A six-year follow-up study. HORMONE RESEARCH IN PAEDIATRICS, 86(3), 196-200 [10.1159/000448841].
Baronio, Federico; Mazzanti, Laura; Girtler, Ylenia; Tamburrino, Federica; Fazzi, Anisia; Lupi, Fiorenzo; Longhi, Silvia; Radetti, Giorgio
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/628379
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