In this case report, the outcomes of cryopreserved ovarian tissue transplantation performed in a patient affected by struma-ovarii associated with mature cystic teratoma, recurrent endometriotic cysts and diffuse peritoneal malignant struma-ovarii implants were described. Before cryopreservation, the patient underwent two left ovarian surgeries for enucleation cysts 8 years after righ salpingo-oophorectomy for struma-ovarii. Ovarian biopsy was collected in another hospital and transported to our laboratory for cryopreservation. The patient was submitted to radioiodine-therapy for metastases from malignant struma-ovarii. After treatment she experienced premature ovarian failure. Ten years after cryopreservation, a first orthotopic transplantation was performed in the left ovary and in a peritoneal pocket. Before transplantation, ovarian samples were analyzed to assess neoplastic contamination and tissue quality. Three years later, a second transplantation was heterotopically performed in abdominal subcutaneous sites. The analysis on thawed ovarian tissue did not reveal micrometastasis and they showed follicle and stroma damages. After transplantation few small follicles were observed at ultrasound examination and hormonal levels remained at menopausal values. To date no ovarian function recovery has been observed. The report highlights that ovarian tissue cryopreservation after multiple ovarian surgery may have some limitations. An accurate counseling should be offered to patients who wish to preserve fertility.

Fabbri, R., Vicenti, R., Paradisi, R., Rossi, S., De Meis, L., Seracchioli, R., et al. (2018). Transplantation of cryopreserved ovarian tissue in a patient affected by metastatic struma ovarii and endometriosis. GYNECOLOGICAL ENDOCRINOLOGY, 34(7), 558-562 [10.1080/09513590.2017.1423468].

Transplantation of cryopreserved ovarian tissue in a patient affected by metastatic struma ovarii and endometriosis

Fabbri, Raffaella
Writing – Original Draft Preparation
;
Vicenti, Rossella
Writing – Original Draft Preparation
;
Paradisi, Roberto
Writing – Review & Editing
;
De Meis, Lucia
Writing – Original Draft Preparation
;
Seracchioli, Renato
Writing – Review & Editing
;
Macciocca, Maria
Writing – Original Draft Preparation
2018

Abstract

In this case report, the outcomes of cryopreserved ovarian tissue transplantation performed in a patient affected by struma-ovarii associated with mature cystic teratoma, recurrent endometriotic cysts and diffuse peritoneal malignant struma-ovarii implants were described. Before cryopreservation, the patient underwent two left ovarian surgeries for enucleation cysts 8 years after righ salpingo-oophorectomy for struma-ovarii. Ovarian biopsy was collected in another hospital and transported to our laboratory for cryopreservation. The patient was submitted to radioiodine-therapy for metastases from malignant struma-ovarii. After treatment she experienced premature ovarian failure. Ten years after cryopreservation, a first orthotopic transplantation was performed in the left ovary and in a peritoneal pocket. Before transplantation, ovarian samples were analyzed to assess neoplastic contamination and tissue quality. Three years later, a second transplantation was heterotopically performed in abdominal subcutaneous sites. The analysis on thawed ovarian tissue did not reveal micrometastasis and they showed follicle and stroma damages. After transplantation few small follicles were observed at ultrasound examination and hormonal levels remained at menopausal values. To date no ovarian function recovery has been observed. The report highlights that ovarian tissue cryopreservation after multiple ovarian surgery may have some limitations. An accurate counseling should be offered to patients who wish to preserve fertility.
2018
Fabbri, R., Vicenti, R., Paradisi, R., Rossi, S., De Meis, L., Seracchioli, R., et al. (2018). Transplantation of cryopreserved ovarian tissue in a patient affected by metastatic struma ovarii and endometriosis. GYNECOLOGICAL ENDOCRINOLOGY, 34(7), 558-562 [10.1080/09513590.2017.1423468].
Fabbri, Raffaella; Vicenti, Rossella*; Paradisi, Roberto; Rossi, Stefania; De Meis, Lucia; Seracchioli, Renato; Macciocca, Maria
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/627779
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