The synthesis and characterization of N-(2-((7-chloroquinolin-4-yl) amino) ethyl) pyrazine-2-carboxamide (L), an aminoquinoline - pyrazinamide hybrid, and the complexes (N-(2-((7-chloroquinolin-4-yl) amino) ethyl) pyrazine-2-carboxamide)(cyclopentadienyl) chlorido-rhodium or iridium hexafluorophosphate ([M(L)(Cp*)Cl] PF6; M = Rh, Ir) and the corresponding chlorido salts ([M(L)(Cp*)Cl] Cl; M = Rh, Ir) are described. The ligand and the hexafluorophosphate salts of the metal complexes have been evaluated for anti-plasmodial and anti-mycobacterial activity. The rhodium and the iridium complexes were significantly more active against M. tuberculosis than the free ligand. The crystallographically determined molecular structures of complexes (N-(2-((7-chloroquinolin-4-yl) amino) ethyl) pyrazine-2-carboxamide)(cyclopentadienyl) chlororhodium hexafluoro-phosphate and (N-(2-((7-chloroquinolin-4-yl) amino) ethyl) pyrazine-2-carboxamide)(cyclopentadienyl) chloro-iridium chloride are presented.
Ekengard, E., Bergare, I., Hansson, J., Doverbratt, I., Monari, M., Gordhan, B., et al. (2017). A pyrazine amide-4-aminoquinoline hybrid and its rhodium and iridium pentamethylcyclopentadienyl complexes; evaluation of anti-mycobacterial and anti-plasmodial activities. JOURNAL OF THE MEXICAN CHEMICAL SOCIETY, 61(2), 158-166 [10.29356/jmcs.v61i2.263].
A pyrazine amide-4-aminoquinoline hybrid and its rhodium and iridium pentamethylcyclopentadienyl complexes; evaluation of anti-mycobacterial and anti-plasmodial activities
Monari, M;
2017
Abstract
The synthesis and characterization of N-(2-((7-chloroquinolin-4-yl) amino) ethyl) pyrazine-2-carboxamide (L), an aminoquinoline - pyrazinamide hybrid, and the complexes (N-(2-((7-chloroquinolin-4-yl) amino) ethyl) pyrazine-2-carboxamide)(cyclopentadienyl) chlorido-rhodium or iridium hexafluorophosphate ([M(L)(Cp*)Cl] PF6; M = Rh, Ir) and the corresponding chlorido salts ([M(L)(Cp*)Cl] Cl; M = Rh, Ir) are described. The ligand and the hexafluorophosphate salts of the metal complexes have been evaluated for anti-plasmodial and anti-mycobacterial activity. The rhodium and the iridium complexes were significantly more active against M. tuberculosis than the free ligand. The crystallographically determined molecular structures of complexes (N-(2-((7-chloroquinolin-4-yl) amino) ethyl) pyrazine-2-carboxamide)(cyclopentadienyl) chlororhodium hexafluoro-phosphate and (N-(2-((7-chloroquinolin-4-yl) amino) ethyl) pyrazine-2-carboxamide)(cyclopentadienyl) chloro-iridium chloride are presented.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
