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EnglishRotor ablation guided by basket catheter mapping has shown to be beneficial for AF ablation. Yet, the initial excitement was mitigated by a growing skepticism due to the difficulty in verifying the protocol in multicenter studies. Overall, the underlying assumptions of rotor ablation require further verification. The aim of this study was therefore to test such hypotheses by using computational modeling. A detailed 3D left atrial geometry of an AF patient was segmented from a pre-operative MR scan. Atrial activation was simulated on the 3D anatomy using the monodomain approach and a variant of the Courtemanche action potential model. Ablated tissue was assigned zero conductivity. Reentry was successfully initialized by applying a single suitably delayed extra stimulus. Unipolar electrograms were computed at the simulated electrode positions. The final dataset was generated by varying location of reentry and catheter position within the LA. The effect of inter-electrode distance and distance to the atrial wall was studied in relation to the ability to recover rotor trajectory, as computed by a novel algorithm described here. The effect of rotor ablation was also assessed.
| Titolo: | A Computational Framework to Benchmark Basket Catheter Guided Ablation |
| Autore/i: | M. Alessandrini; M. Valinoti; A. Loewe; T. Oesterlein; O. Dössel; C. Corsi; S. Severi |
| Autore/i Unibo: | |
| Anno: | 2017 |
| Rivista: | |
| Titolo del libro: | Computing in Cardiology |
| Pagina iniziale: | 1 |
| Pagina finale: | 4 |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.22489/CinC.2017.376-371 |
| Abstract: | Rotor ablation guided by basket catheter mapping has shown to be beneficial for AF ablation. Yet, the initial excitement was mitigated by a growing skepticism due to the difficulty in verifying the protocol in multicenter studies. Overall, the underlying assumptions of rotor ablation require further verification. The aim of this study was therefore to test such hypotheses by using computational modeling. A detailed 3D left atrial geometry of an AF patient was segmented from a pre-operative MR scan. Atrial activation was simulated on the 3D anatomy using the monodomain approach and a variant of the Courtemanche action potential model. Ablated tissue was assigned zero conductivity. Reentry was successfully initialized by applying a single suitably delayed extra stimulus. Unipolar electrograms were computed at the simulated electrode positions. The final dataset was generated by varying location of reentry and catheter position within the LA. The effect of inter-electrode distance and distance to the atrial wall was studied in relation to the ability to recover rotor trajectory, as computed by a novel algorithm described here. The effect of rotor ablation was also assessed. |
| Data stato definitivo: | 8-apr-2019 |
| Appare nelle tipologie: | 4.01 Contributo in Atti di convegno |
File in questo prodotto:
| File | Descrizione | Tipo | Licenza | |
|---|---|---|---|---|
| 376-371.pdf | Versione (PDF) editoriale | Licenza per Accesso Aperto. Creative Commons Attribuzione (CCBY) | Open Access Visualizza/Apri |
http://hdl.handle.net/11585/626927
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