The thus-far unknown ureic derivative dimethyl 2,2′-[carbonylbis(azanediyl)](2S,2′S)-bis[3-(4-hydroxyphenyl)propanoate] has been efficiently synthesized by enantiospecific oxidative carbonylation of readily available l-tyrosine methyl ester, using a very simple catalytic system (PdI2 in conjunction with KI) under relatively mild conditions (100 °C for 5 h in DME as the solvent and under 20 atm of a 4:1 mixture CO-air).
Raffaella Mancuso, K.F.G. (2018). Dimethyl 2,2'-[Carbonylbis(azanediyl)](2S,2'S)-bis[3-(4-hydroxyphenyl)propanoate]. MOLBANK, 2018(1), M983-M983 [10.3390/M983].
Dimethyl 2,2'-[Carbonylbis(azanediyl)](2S,2'S)-bis[3-(4-hydroxyphenyl)propanoate]
Carla Carfagna;
2018
Abstract
The thus-far unknown ureic derivative dimethyl 2,2′-[carbonylbis(azanediyl)](2S,2′S)-bis[3-(4-hydroxyphenyl)propanoate] has been efficiently synthesized by enantiospecific oxidative carbonylation of readily available l-tyrosine methyl ester, using a very simple catalytic system (PdI2 in conjunction with KI) under relatively mild conditions (100 °C for 5 h in DME as the solvent and under 20 atm of a 4:1 mixture CO-air).File in questo prodotto:
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