OBJECTIVE: At present, there is growing evidence of the existence of a genetic predisposition in both thrombophilic disorders and endometriosis. The aim of our study was to evaluate for the first time the prevalence of some thrombophilic disorders in patients with endometriosis. MATERIALS AND METHODS: We conducted a retrospective study on 138 patients with endometriosis and 278 healthy control women. All women were subjected to a blood examination testing for thrombophilic screening and the variables examinated were: hyperhomocysteinemia, factor V Leiden and factor II prothrombin G20210A mutations in heterozygosis and homozigosis. RESULTS: A significant reduced prevalence (p < 0.05) of factor V Leiden mutation in endometriosis patients was found, whereas no significant differences (p = NS) for factor II and hyperhomocysteinemia were observed. CONCLUSION: Our preliminary data do not show any association between thrombophilic condition and endometriosis. Before assuming hormonal therapies, a thrombophilic plasmatic screening seems to be unnecessary in patients affected by endometriosis.

Does exist a correlation between endometriosis and thrombophilic disorders? A pilot study / Paradisi R, Ferrini G, Matteucci C, Facchini C, Zannoni L, Seracchioli R. - In: TAIWANESE JOURNAL OF OBSTETRICS AND GYNECOLOGY. - ISSN 1028-4559. - STAMPA. - 56:3(2017), pp. 371-373. [10.1016/j.tjog.2017.04.020]

Does exist a correlation between endometriosis and thrombophilic disorders? A pilot study.

Paradisi R;Ferrini G
;
Matteucci C;Facchini C;Zannoni L;Seracchioli R
2017

Abstract

OBJECTIVE: At present, there is growing evidence of the existence of a genetic predisposition in both thrombophilic disorders and endometriosis. The aim of our study was to evaluate for the first time the prevalence of some thrombophilic disorders in patients with endometriosis. MATERIALS AND METHODS: We conducted a retrospective study on 138 patients with endometriosis and 278 healthy control women. All women were subjected to a blood examination testing for thrombophilic screening and the variables examinated were: hyperhomocysteinemia, factor V Leiden and factor II prothrombin G20210A mutations in heterozygosis and homozigosis. RESULTS: A significant reduced prevalence (p < 0.05) of factor V Leiden mutation in endometriosis patients was found, whereas no significant differences (p = NS) for factor II and hyperhomocysteinemia were observed. CONCLUSION: Our preliminary data do not show any association between thrombophilic condition and endometriosis. Before assuming hormonal therapies, a thrombophilic plasmatic screening seems to be unnecessary in patients affected by endometriosis.
2017
Does exist a correlation between endometriosis and thrombophilic disorders? A pilot study / Paradisi R, Ferrini G, Matteucci C, Facchini C, Zannoni L, Seracchioli R. - In: TAIWANESE JOURNAL OF OBSTETRICS AND GYNECOLOGY. - ISSN 1028-4559. - STAMPA. - 56:3(2017), pp. 371-373. [10.1016/j.tjog.2017.04.020]
Paradisi R, Ferrini G, Matteucci C, Facchini C, Zannoni L, Seracchioli R
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/626450
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