Werner syndrome is a progeroid disorder characterized by premature age-related phenotypes. Although it is well established that autosomal recessive mutations in the WRN gene is responsible for Werner syndrome, the molecular alterations that lead to disease phenotype remain still unidentified.
Guastafierro, T., Bacalini, M.G., Marcoccia, A., Gentilini, D., Pisoni, S., Di Blasio, A.M., et al. (2017). Genome-wide DNA methylation analysis in blood cells from patients with Werner syndrome. CLINICAL EPIGENETICS, 9, 1-10 [10.1186/s13148-017-0389-4].
Genome-wide DNA methylation analysis in blood cells from patients with Werner syndrome
Bacalini, MG;Franceschi, C;Garagnani, P;
2017
Abstract
Werner syndrome is a progeroid disorder characterized by premature age-related phenotypes. Although it is well established that autosomal recessive mutations in the WRN gene is responsible for Werner syndrome, the molecular alterations that lead to disease phenotype remain still unidentified.File in questo prodotto:
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