In this work, gelatin was crosslinked with oxidized alginate in the presence of borax yielding a hybrid biohydrogel system with the ability to self-repair upon mechanical damage. A judicious balance between concentration, stoichiometric ratio of the two biopolymers and gelatin source was found necessary to achieve optimal self-healing properties of these biohydrogels. The pH was found to have a major influence on the reconstruction of the damaged hydrogel interface, confirming that the dynamic Schiff base linkages between the amine groups of gelatin and the aldehyde groups of oxidized alginate play a fundamental role on the healing process of the hybrid gels.
Asja Pettignano, Marleen Häring, Luca Bernardi, Nathalie Tanchoux, Fran\ccoise Quignard, David D\'\iaz D\'\iaz (2017). Self-healing alginate-gelatin biohydrogels based on dynamic covalent chemistry: elucidation of key parameters. MATERIALS CHEMISTRY FRONTIERS, 1, 73-79 [10.1039/c6qm00066e].
Self-healing alginate-gelatin biohydrogels based on dynamic covalent chemistry: elucidation of key parameters
Asja Pettignano;Luca Bernardi;
2017
Abstract
In this work, gelatin was crosslinked with oxidized alginate in the presence of borax yielding a hybrid biohydrogel system with the ability to self-repair upon mechanical damage. A judicious balance between concentration, stoichiometric ratio of the two biopolymers and gelatin source was found necessary to achieve optimal self-healing properties of these biohydrogels. The pH was found to have a major influence on the reconstruction of the damaged hydrogel interface, confirming that the dynamic Schiff base linkages between the amine groups of gelatin and the aldehyde groups of oxidized alginate play a fundamental role on the healing process of the hybrid gels.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.