A Rare Case of Epididymal Metastasis After Radical Prostatectomy Detected by 68Ga-PSMA PET/CT.

Disease relapse occurs within 10 years from primary treatment in the 30% of patients who underwent radical therapy for prostate cancer. In the majority of cases, the disease relapse occurs in lymph nodes or bone. Lung, liver, pleura, and brain are rarely described as site of relapse. However, other uncommon sites of the disease are described in literature. In patients with a high risk of recurrence, positron emission tomography/computed tomography imaging plays a fundamental role in detecting the site of relapse. Thus, an early detection of the recurrence is important in order to refer patients to metastasisdirected therapy. We report a case of a patient with biochemical relapse and right epididymis 68Ga-prostate-specific membrane antigen uptake who underwent an orchiectomy, according to positron emission tomography/ computed tomography results. Histologic analysis of the specimen revealed the presence of prostate cancer cell diffusion. A biochemical response after surgery was observed (baseline prostate-specific antigen levels ¼ 0.56 ng/ mL; postsurgery prostate-specific antigen levels ¼ 0.12 ng/mL)