Introduction Serum uric acid (SUA) has been associated to incident hypertension and increased risk of cardiovascular diseases. Materials and methods Among the 2191 subjects enrolled during the last population survey of the Brisighella Heart Study, we identified 146 new cases of arterial hypertension and 394 treated but uncontrolled hypertensive patients with different levels of SUA. Their hemodynamic characteristics have been compared with those of age- and sex-matched normotensive (N. 324) and controlled hypertensive (N. 470) subjects. Then, by logistic regression analysis, we evaluated which factors were associated with a worse BP control under pharmacological treatment. Results SUA levels were significantly higher in untreated hypertensive and uncontrolled hypertensive patients when compared to normotensives and controlled hypertensive patients. Pulse wave velocity (PWV) was significantly higher (pÂ
Cicero, A.F.G., Rosticci, M., Fogacci, F., Grandi, E., D'Addato, S., Borghi, C. (2017). High serum uric acid is associated to poorly controlled blood pressure and higher arterial stiffness in hypertensive subjects. EUROPEAN JOURNAL OF INTERNAL MEDICINE, 37, 38-42 [10.1016/j.ejim.2016.07.026].
High serum uric acid is associated to poorly controlled blood pressure and higher arterial stiffness in hypertensive subjects
Cicero, Arrigo F. G.
Writing – Original Draft Preparation
;Rosticci, Martina
Membro del Collaboration Group
;Grandi, Elisa
Membro del Collaboration Group
;D'Addato, Sergio
Project Administration
;Borghi, Claudio
Writing – Review & Editing
2017
Abstract
Introduction Serum uric acid (SUA) has been associated to incident hypertension and increased risk of cardiovascular diseases. Materials and methods Among the 2191 subjects enrolled during the last population survey of the Brisighella Heart Study, we identified 146 new cases of arterial hypertension and 394 treated but uncontrolled hypertensive patients with different levels of SUA. Their hemodynamic characteristics have been compared with those of age- and sex-matched normotensive (N. 324) and controlled hypertensive (N. 470) subjects. Then, by logistic regression analysis, we evaluated which factors were associated with a worse BP control under pharmacological treatment. Results SUA levels were significantly higher in untreated hypertensive and uncontrolled hypertensive patients when compared to normotensives and controlled hypertensive patients. Pulse wave velocity (PWV) was significantly higher (pÂI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
