C60@lysozyme showed significant visible light-induced singlet oxygen generation in water, indicating the potential of this hybrid as an agent for photodynamic therapy. The reactive oxygen species (ROS) concentration generated by C60@lysozyme during irradiation depends on the light source, the irradiation time and the concentration of the hybrid. C60@lysozyme significantly reduced the HeLa cell viability in response to visible light irradiation. The generation of H2O2, due to the photoactivity of C60@lysozyme, causes cell death via easy permeation of hydrogen peroxide through the cell membrane and activation of endogenous ROS production.

C60@lysozyme: A new photosensitizing agent for photodynamic therapy

Cantelli, A.;Di Giosia, M.;Montalti, M.;Zerbetto, F.;Rapino, S.;Calvaresi, M.
2017

Abstract

C60@lysozyme showed significant visible light-induced singlet oxygen generation in water, indicating the potential of this hybrid as an agent for photodynamic therapy. The reactive oxygen species (ROS) concentration generated by C60@lysozyme during irradiation depends on the light source, the irradiation time and the concentration of the hybrid. C60@lysozyme significantly reduced the HeLa cell viability in response to visible light irradiation. The generation of H2O2, due to the photoactivity of C60@lysozyme, causes cell death via easy permeation of hydrogen peroxide through the cell membrane and activation of endogenous ROS production.
Soldã , A.; Cantelli, A.; Di Giosia, M.; Montalti, M.; Zerbetto, F.; Rapino, S.; Calvaresi, M.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/616887
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