The mitochondrial F1FO-ATPase has the main role in synthesizing most of ATP, thus providing energy to living cells, but it also works in reverse and hydrolyzes ATP, depending on the transmembrane electrochemical gradient. Within the same complex the vital role of the enzyme of life coexists with that of molecular switch to trigger programmed cell death. The two-faced vital/lethal role makes the enzyme complex an intriguing biochemical target to fight pathogens resistant to traditional therapies and diseases linked to mitochondrial dysfunctions. A variety of post-translational modifications (PTMs) of selected F1FO-ATPase aminoacids have been reported to affect the enzyme function.

Nesci, S., Trombetti, F., Ventrella, V., Pagliarani, A. (2017). Post-translational modifications of the mitochondrial F1FO-ATPase. BIOCHIMICA ET BIOPHYSICA ACTA, 1861(11 Pt A), 2902-2912 [10.1016/j.bbagen.2017.08.007].

Post-translational modifications of the mitochondrial F1FO-ATPase

NESCI, SALVATORE;TROMBETTI, FABIANA;VENTRELLA, VITTORIA;PAGLIARANI, ALESSANDRA
2017

Abstract

The mitochondrial F1FO-ATPase has the main role in synthesizing most of ATP, thus providing energy to living cells, but it also works in reverse and hydrolyzes ATP, depending on the transmembrane electrochemical gradient. Within the same complex the vital role of the enzyme of life coexists with that of molecular switch to trigger programmed cell death. The two-faced vital/lethal role makes the enzyme complex an intriguing biochemical target to fight pathogens resistant to traditional therapies and diseases linked to mitochondrial dysfunctions. A variety of post-translational modifications (PTMs) of selected F1FO-ATPase aminoacids have been reported to affect the enzyme function.
2017
Nesci, S., Trombetti, F., Ventrella, V., Pagliarani, A. (2017). Post-translational modifications of the mitochondrial F1FO-ATPase. BIOCHIMICA ET BIOPHYSICA ACTA, 1861(11 Pt A), 2902-2912 [10.1016/j.bbagen.2017.08.007].
Nesci, Salvatore; Trombetti, Fabiana; Ventrella, Vittoria; Pagliarani, Alessandra
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/613486
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