Fusarium spp. are an uncommon cause of fungaemia in immunocompromised and neutropenic patients that may hematogenously disseminate to the eyes. Herein, we describe a patient with acute lymphoblastic leukaemia and a prior history of extensive corticosteroid exposure who developed disseminated Fusarium solani infection following chemotherapy despite posaconazole prophylaxis. She was successfully treated with combination liposomal amphotericin B and voriconazole, intraocular injections of voriconazole, topical amphotericin B and bilateral vitrectomy. We also review published literature describing the management of endogenous Fusarium endophthalmitis in immunocompromised hosts.

Successful treatment of bilateral endogenous Fusarium solani endophthalmitis in a patient with acute lymphocytic leukaemia

Rizzello, Ilaria;Castagnetti, Fausto;Toschi, Pier Giorgio;Bertaccini, Patrizia;Primavera, Laura;Paolucci, Michela;Spinardi, Luca;Lewis, Russell E.;Cavo, Michele;Stanzani, Marta
2018

Abstract

Fusarium spp. are an uncommon cause of fungaemia in immunocompromised and neutropenic patients that may hematogenously disseminate to the eyes. Herein, we describe a patient with acute lymphoblastic leukaemia and a prior history of extensive corticosteroid exposure who developed disseminated Fusarium solani infection following chemotherapy despite posaconazole prophylaxis. She was successfully treated with combination liposomal amphotericin B and voriconazole, intraocular injections of voriconazole, topical amphotericin B and bilateral vitrectomy. We also review published literature describing the management of endogenous Fusarium endophthalmitis in immunocompromised hosts.
Rizzello, Ilaria; Castagnetti, Fausto; Toschi, Pier Giorgio; Bertaccini, Patrizia; Primavera, Laura; Paolucci, Michela; Faccioli, Luca; Spinardi, Luca; Lewis, Russell E.; Cavo, Michele; Stanzani, Marta
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/613384
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