URPOSE: To assess the contribution of Italian radiation oncologists in the current management of recurrent high-grade gliomas (HGG), focusing on a reirradiation (reRT) approach. METHODS: In 2015, the Reirradiation and the Central Nervous System Study Groups on behalf of the Italian Association of Radiation Oncology (AIRO) proposed a survey. All Italian radiation oncologists were individually invited to complete an online questionnaire regarding their clinical management of recurrent HGG, focusing on a reRT approach. RESULTS: A total of 37 of 210 questionnaires were returned (18% of all centers): 16 (43%) from nonacademic hospitals, 14 (38%) from academic hospitals, 5 (13%) from private institutions, and 2 (6%) from hadron therapy centers. The majority of responding centers (59%) treated ≤5 cases per year. Performance status at the time of recurrence, along with a target diameter <5 cm and an interval from primary radiation ≥6 months, were the prevalent predictive factors considered for reRT. Sixty percent of reirradiated patients had already received a salvage therapy, either chemotherapy (40%) or reoperation (20%). The most common approach for reRT was fractionated stereotactic radiotherapy to a mean (photon) dose of 41.6 Gy. CONCLUSIONS: Although there were wide variations in the clinical practice of reRT across the 37 centers, the core activities were reasonably consistent. These findings provide a basis for encouraging a national collaborative study to develop, implement, and monitor the use of reRT in this challenging clinical setting.
Policies for reirradiation of recurrent high-grade gliomas: a survey among Italian radiation oncologists / Furlan, Carlo; Arcangeli, Stefano; Avanzo, Michele; Mirri, Maria A; Munoz, Fernando; Giudici, Stefania; Perrone, Antonio; Amelio, Dante; Tomio, Luigi; Draghini, Loredana; Deli, Aniko M; Pavanato, Giovanni; Giugliano, Francesca M; Pontoriero, Antonio; Ciammella, Patrizia; Navarria, Pierina; Iannalfi, Alberto; Buglione, Michela; Guida, Cesare; Cammelli, Silvia; Iorio, Vincenzo; Cardinali, Massimo; Genovesi, Domenico; Barsacchi, Lucia; Balducci, Mario; Bagnoli, Rita; Berti, Franco; Montesi, Giampaolo; Pasqualetti, Francesco; Bonome, Paolo; Santoni, Riccardo; Doino, Daniela; Schirru, Patrizia; Pinzi, Valentina; Borzillo, Valentina; Ferrarese, Fabio; Ferro, Marica; De Cicco, Luigi; Krengli, Marco; Scoccianti, Silvia; Donato, Vittorio. - In: TUMORI. - ISSN 0300-8916. - ELETTRONICO. - 104:6(2018), pp. 466-470. [10.5301/tj.5000615]
Policies for reirradiation of recurrent high-grade gliomas: a survey among Italian radiation oncologists
CAMMELLI, SILVIA;
2018
Abstract
URPOSE: To assess the contribution of Italian radiation oncologists in the current management of recurrent high-grade gliomas (HGG), focusing on a reirradiation (reRT) approach. METHODS: In 2015, the Reirradiation and the Central Nervous System Study Groups on behalf of the Italian Association of Radiation Oncology (AIRO) proposed a survey. All Italian radiation oncologists were individually invited to complete an online questionnaire regarding their clinical management of recurrent HGG, focusing on a reRT approach. RESULTS: A total of 37 of 210 questionnaires were returned (18% of all centers): 16 (43%) from nonacademic hospitals, 14 (38%) from academic hospitals, 5 (13%) from private institutions, and 2 (6%) from hadron therapy centers. The majority of responding centers (59%) treated ≤5 cases per year. Performance status at the time of recurrence, along with a target diameter <5 cm and an interval from primary radiation ≥6 months, were the prevalent predictive factors considered for reRT. Sixty percent of reirradiated patients had already received a salvage therapy, either chemotherapy (40%) or reoperation (20%). The most common approach for reRT was fractionated stereotactic radiotherapy to a mean (photon) dose of 41.6 Gy. CONCLUSIONS: Although there were wide variations in the clinical practice of reRT across the 37 centers, the core activities were reasonably consistent. These findings provide a basis for encouraging a national collaborative study to develop, implement, and monitor the use of reRT in this challenging clinical setting.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
