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EnglishPurpose: The present paper sought investigate the existence of parameters useful for predicting lymph node metastases in cases of surgically resected oral squamous cell carcinomas (OSCC). Fifty-eight cases were studied for E-Cadherin and the truncated dominant-negative isoform of p63 (Np63) with immunohistochemistry. In addition, the p63 gene expression profile was evaluated by RT-PCR to disclose the presence of the truncated variant Np73L. Results: E-Cadherin expression was the most powerful parameter related to the presence of lymph node metastases at presentation. Twenty-four cases out of 38 (63%) showing low E-Cadherin expression had lymph node metastases at presentation as compared to 5 out of 20 (25%) ( P<0.01) cases showing high E-Cadherin expression. The high predictive value was also maintained when a low expression of E-Cadherin was associated immunohistochemical high expression of Np63. The association between low E-Cadherin expression and Np73L (as seen with RT-PCR) was highly predictive for developing lymph node metastases, especially in small tumours (T1T2). When this association occurred, metastases developed in 62.5% of cases during the follow-up as compared to 16.1% in those which did not show low E-Cadherin expression and a Np73L presence. Conclusion: The present study shows that low E-Cadherin expression is useful for predicting lymph node metastases in cases of OSCC. The predictive value is enhanced when low E-Cadherin positivity is associated with Np63 and Np73L expression.
| Titolo: | E-cadherin loss and Delta Np73L expression in oral squamous cell carcinomas showing aggressive behavior |
| Autore/i: | FOSCHINI, MARIA PIA; COCCHI, ROBERTO; MORANDI, LUCA; MARUCCI, GIANLUCA; M. G. Pennesi; RIGHI, ALBERTO; A. L. Tosi; DE BIASE, DARIO; PESSION, ANNALISA; MONTEBUGNOLI, LUCIO |
| Autore/i Unibo: | |
| Anno: | 2008 |
| Rivista: | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1002/hed.20908 |
| Abstract: | Purpose: The present paper sought investigate the existence of parameters useful for predicting lymph node metastases in cases of surgically resected oral squamous cell carcinomas (OSCC). Fifty-eight cases were studied for E-Cadherin and the truncated dominant-negative isoform of p63 (Np63) with immunohistochemistry. In addition, the p63 gene expression profile was evaluated by RT-PCR to disclose the presence of the truncated variant Np73L. Results: E-Cadherin expression was the most powerful parameter related to the presence of lymph node metastases at presentation. Twenty-four cases out of 38 (63%) showing low E-Cadherin expression had lymph node metastases at presentation as compared to 5 out of 20 (25%) ( P<0.01) cases showing high E-Cadherin expression. The high predictive value was also maintained when a low expression of E-Cadherin was associated immunohistochemical high expression of Np63. The association between low E-Cadherin expression and Np73L (as seen with RT-PCR) was highly predictive for developing lymph node metastases, especially in small tumours (T1T2). When this association occurred, metastases developed in 62.5% of cases during the follow-up as compared to 16.1% in those which did not show low E-Cadherin expression and a Np73L presence. Conclusion: The present study shows that low E-Cadherin expression is useful for predicting lymph node metastases in cases of OSCC. The predictive value is enhanced when low E-Cadherin positivity is associated with Np63 and Np73L expression. |
| Data prodotto definitivo in UGOV: | 2008-11-18 16:06:35 |
| Appare nelle tipologie: | 1.01 Articolo in rivista |
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http://hdl.handle.net/11585/60992
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