The reaction of benzothiadiphosphole 1 with an equimolar mixture of R 1 MgBr and R 2 MgBr gave intermediate A¢, which, after only 4-5 min, was treated with an equimolar amount of R 3 MgBr, giving the asymmetric phosphine PR 1 R 2 R 3 in 45% overall yield (75-80% yield when R 1 ) R 2 and 85-90% yield when R 1 ) R 2 ) R 3 ) and the byproduct 6 in 90% yield. The treatment of 6 with PCl3 quantitatively regenerates the starting reagent 1. Treatment of the phosphines with elemental sulfur gave the corresponding sulfides.

G. Baccolini, C. Boga, M. Mazzacurati (2005). Highly Atom-Economic One-Pot Formation of Three Different C-P Bonds: General Synthesis of Acyclic Tertiary Phosphine Sulfides. JOURNAL OF ORGANIC CHEMISTRY, 70, 4774-4777 [10.1021/jo0502145].

Highly Atom-Economic One-Pot Formation of Three Different C-P Bonds: General Synthesis of Acyclic Tertiary Phosphine Sulfides

BACCOLINI, GRAZIANO;BOGA, CARLA;MAZZACURATI, MARZIA
2005

Abstract

The reaction of benzothiadiphosphole 1 with an equimolar mixture of R 1 MgBr and R 2 MgBr gave intermediate A¢, which, after only 4-5 min, was treated with an equimolar amount of R 3 MgBr, giving the asymmetric phosphine PR 1 R 2 R 3 in 45% overall yield (75-80% yield when R 1 ) R 2 and 85-90% yield when R 1 ) R 2 ) R 3 ) and the byproduct 6 in 90% yield. The treatment of 6 with PCl3 quantitatively regenerates the starting reagent 1. Treatment of the phosphines with elemental sulfur gave the corresponding sulfides.
2005
G. Baccolini, C. Boga, M. Mazzacurati (2005). Highly Atom-Economic One-Pot Formation of Three Different C-P Bonds: General Synthesis of Acyclic Tertiary Phosphine Sulfides. JOURNAL OF ORGANIC CHEMISTRY, 70, 4774-4777 [10.1021/jo0502145].
G. Baccolini; C. Boga; M. Mazzacurati
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/6048
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