The first general protocol for the anti-selective reduction of α-alkyl-b-keto amides is described. This simple and efficient methodology based on an open-chain Felkin-Anh model pathway, allows the isolation of N-mono- and non-substituted anti-a-substituted b-hydroxy amides in good yields and with high diastereoselectivity.
Highly Stereoselective Reduction of β-Keto Amides. The First General and Efficient Approach to N-Mono- and Non-Substituted anti-α-Alkyl β-Hydroxy Amides / G. Bartoli; M. Bosco; E. Marcantoni; P. Melchiorre; S. Rinaldi; L. Sambri. - In: SYNLETT. - ISSN 0936-5214. - STAMPA. - 0:(2004), pp. 73-76. [10.1055/s-2003-43354]
Highly Stereoselective Reduction of β-Keto Amides. The First General and Efficient Approach to N-Mono- and Non-Substituted anti-α-Alkyl β-Hydroxy Amides
BARTOLI, GIUSEPPE;BOSCO, MARCELLA;MELCHIORRE, PAOLO;RINALDI, SAMUELE;SAMBRI, LETIZIA
2004
Abstract
The first general protocol for the anti-selective reduction of α-alkyl-b-keto amides is described. This simple and efficient methodology based on an open-chain Felkin-Anh model pathway, allows the isolation of N-mono- and non-substituted anti-a-substituted b-hydroxy amides in good yields and with high diastereoselectivity.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
