The first general protocol for the anti-selective reduction of α-alkyl-b-keto amides is described. This simple and efficient methodology based on an open-chain Felkin-Anh model pathway, allows the isolation of N-mono- and non-substituted anti-a-substituted b-hydroxy amides in good yields and with high diastereoselectivity.
G. Bartoli, M. Bosco, E. Marcantoni, P. Melchiorre, S. Rinaldi, L. Sambri (2004). Highly Stereoselective Reduction of β-Keto Amides. The First General and Efficient Approach to N-Mono- and Non-Substituted anti-α-Alkyl β-Hydroxy Amides. SYNLETT, 0, 73-76 [10.1055/s-2003-43354].
Highly Stereoselective Reduction of β-Keto Amides. The First General and Efficient Approach to N-Mono- and Non-Substituted anti-α-Alkyl β-Hydroxy Amides
BARTOLI, GIUSEPPE;BOSCO, MARCELLA;MELCHIORRE, PAOLO;RINALDI, SAMUELE;SAMBRI, LETIZIA
2004
Abstract
The first general protocol for the anti-selective reduction of α-alkyl-b-keto amides is described. This simple and efficient methodology based on an open-chain Felkin-Anh model pathway, allows the isolation of N-mono- and non-substituted anti-a-substituted b-hydroxy amides in good yields and with high diastereoselectivity.File in questo prodotto:
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