The first general protocol for the anti-selective reduction of α-alkyl-b-keto amides is described. This simple and efficient methodology based on an open-chain Felkin-Anh model pathway, allows the isolation of N-mono- and non-substituted anti-a-substituted b-hydroxy amides in good yields and with high diastereoselectivity.

G. Bartoli, M. Bosco, E. Marcantoni, P. Melchiorre, S. Rinaldi, L. Sambri (2004). Highly Stereoselective Reduction of β-Keto Amides. The First General and Efficient Approach to N-Mono- and Non-Substituted anti-α-Alkyl β-Hydroxy Amides. SYNLETT, 0, 73-76 [10.1055/s-2003-43354].

Highly Stereoselective Reduction of β-Keto Amides. The First General and Efficient Approach to N-Mono- and Non-Substituted anti-α-Alkyl β-Hydroxy Amides

BARTOLI, GIUSEPPE;BOSCO, MARCELLA;MELCHIORRE, PAOLO;RINALDI, SAMUELE;SAMBRI, LETIZIA
2004

Abstract

The first general protocol for the anti-selective reduction of α-alkyl-b-keto amides is described. This simple and efficient methodology based on an open-chain Felkin-Anh model pathway, allows the isolation of N-mono- and non-substituted anti-a-substituted b-hydroxy amides in good yields and with high diastereoselectivity.
2004
G. Bartoli, M. Bosco, E. Marcantoni, P. Melchiorre, S. Rinaldi, L. Sambri (2004). Highly Stereoselective Reduction of β-Keto Amides. The First General and Efficient Approach to N-Mono- and Non-Substituted anti-α-Alkyl β-Hydroxy Amides. SYNLETT, 0, 73-76 [10.1055/s-2003-43354].
G. Bartoli; M. Bosco; E. Marcantoni; P. Melchiorre; S. Rinaldi; L. Sambri
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/6022
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