Phosphanes: No pain, all gain. A regenerable phosphorus donor is the key to an efficient and economic one-pot synthesis of five- and six-membered secondary cyclic phosphanes. The reaction, at room temperature, of 1 with 1 equivalent of bis(Grignard reagent) 2 followed by treatment with aqueous acid gives cyclic phosphanes 3 in 70-80 % yield and the new compound 4. Simply treating 4 with PCl3 quantitatively regenerates the starting reagent 1, which can be reused without further purification.
G. Baccolini, C. Boga, M. Galeotti (2004). Efficient One-Pot Synthesis of Secondary Cyclic Phosphanes with Easy Regeneration of the Phosphorus-Donor Reagent Used. ANGEWANDTE CHEMIE. INTERNATIONAL EDITION, 43, 3058-3060 [10.1002/anie.200453820].
Efficient One-Pot Synthesis of Secondary Cyclic Phosphanes with Easy Regeneration of the Phosphorus-Donor Reagent Used
BACCOLINI, GRAZIANO;BOGA, CARLA;
2004
Abstract
Phosphanes: No pain, all gain. A regenerable phosphorus donor is the key to an efficient and economic one-pot synthesis of five- and six-membered secondary cyclic phosphanes. The reaction, at room temperature, of 1 with 1 equivalent of bis(Grignard reagent) 2 followed by treatment with aqueous acid gives cyclic phosphanes 3 in 70-80 % yield and the new compound 4. Simply treating 4 with PCl3 quantitatively regenerates the starting reagent 1, which can be reused without further purification.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
