Context: Growth hormone (GH) influences glucose homeostasis mainly by negatively affecting insulin sensitivity. Objective: To longitudinally study insulin sensitivity [via homeostasis model assessment of insulin sensitivity (HOMA-S)], insulin secretion [insulinogenic index (IGI)], and capacity of b cells to adapt to changes in insulin sensitivity [oral disposition index (ODI)] in girls with Turner syndrome (TS) undergoing GH treatment. Design and Setting: Longitudinal, retrospective, 7-year study conducted in a tertiary pediatric endocrine unit and university pediatric clinic. Patients and Methods:We studied 104 patientswith TS (mean age6standard deviation, 9.163.4 years) for a median of 7.2 years. Intervention: Every year, the children underwent an oral glucose tolerance test, which was used to calculate HOMA-S, IGI, and ODI. Results: HOMA-S, IGI, and ODI did not significantly change. Conclusion: The results are reassuring, showing no negative influence of GH treatment on insulin sensitivity and on b-cell secretory capacity in girlswith TS.

Baronio, F., Mazzanti, L., Girtler, Y., Tamburrino, F., Lupi, F., Longhi, S., et al. (2017). The influence of gh treatment on glucose homeostasis in girls with turner syndrome: A 7-year study. THE JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM, 102(3), 878-883 [10.1210/jc.2016-3179].

The influence of gh treatment on glucose homeostasis in girls with turner syndrome: A 7-year study

MAZZANTI, LAURA;
2017

Abstract

Context: Growth hormone (GH) influences glucose homeostasis mainly by negatively affecting insulin sensitivity. Objective: To longitudinally study insulin sensitivity [via homeostasis model assessment of insulin sensitivity (HOMA-S)], insulin secretion [insulinogenic index (IGI)], and capacity of b cells to adapt to changes in insulin sensitivity [oral disposition index (ODI)] in girls with Turner syndrome (TS) undergoing GH treatment. Design and Setting: Longitudinal, retrospective, 7-year study conducted in a tertiary pediatric endocrine unit and university pediatric clinic. Patients and Methods:We studied 104 patientswith TS (mean age6standard deviation, 9.163.4 years) for a median of 7.2 years. Intervention: Every year, the children underwent an oral glucose tolerance test, which was used to calculate HOMA-S, IGI, and ODI. Results: HOMA-S, IGI, and ODI did not significantly change. Conclusion: The results are reassuring, showing no negative influence of GH treatment on insulin sensitivity and on b-cell secretory capacity in girlswith TS.
2017
Baronio, F., Mazzanti, L., Girtler, Y., Tamburrino, F., Lupi, F., Longhi, S., et al. (2017). The influence of gh treatment on glucose homeostasis in girls with turner syndrome: A 7-year study. THE JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM, 102(3), 878-883 [10.1210/jc.2016-3179].
Baronio, Federico; Mazzanti, Laura; Girtler, Ylenia; Tamburrino, Federica; Lupi, Fiorenzo; Longhi, Silvia; Fanolla, Antonio; Radetti, Giorgio
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/601047
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