The influence of age and sex on chemotherapy-related toxicity was evaluated in children and adults with non metastatic osteosarcoma. Treatment consisted of methotrexate (MTX, 12 g/m2), cisplatin (CDP 120 mg/m2) and doxorubicin (ADM 75-90 mg/m2) and high-dose ifosfamide (HDIFO). Toxicity data from 1,051 courses (295 with MTX, 756 based on doxorubicin, cisplatin and high-dose ifosfamide) were analyzed. Children (4-14 yrs) and females showed a higher incidence of grade 4 neu-tropenia and thrombocytopenia and were more frequently hospitalized for neutropenic fever compared to adolescents and young adults (AYA, 15-19 yrs) and adults (>20-40 yrs). Delayed MTX excretion was higher in adults than AYA and children. Adults (up to 40 years) can be treated with pediatric protocols for osteosarcoma and they experience lower hematologic toxicity compared to pediatric population. Further investigations on sex-related susceptibility to chemotherapy in osteosarcoma patients are recommended.
Ferrari, S., Palmerini, E., Staals, E., Abate, M., Longhi, A., Cesari, M., et al. (2009). Sex- and age-related chemotherapy toxicity in patients with non-metastatic osteosarcoma. JOURNAL OF CHEMOTHERAPY, 21(2), 205-210 [10.1179/joc.2009.21.2.205].
Sex- and age-related chemotherapy toxicity in patients with non-metastatic osteosarcoma
FERRARI, STEFANO;PALMERINI, EMANUELA;STAALS, ERIC LODEWIJK;LONGHI, ALESSANDRA;
2009
Abstract
The influence of age and sex on chemotherapy-related toxicity was evaluated in children and adults with non metastatic osteosarcoma. Treatment consisted of methotrexate (MTX, 12 g/m2), cisplatin (CDP 120 mg/m2) and doxorubicin (ADM 75-90 mg/m2) and high-dose ifosfamide (HDIFO). Toxicity data from 1,051 courses (295 with MTX, 756 based on doxorubicin, cisplatin and high-dose ifosfamide) were analyzed. Children (4-14 yrs) and females showed a higher incidence of grade 4 neu-tropenia and thrombocytopenia and were more frequently hospitalized for neutropenic fever compared to adolescents and young adults (AYA, 15-19 yrs) and adults (>20-40 yrs). Delayed MTX excretion was higher in adults than AYA and children. Adults (up to 40 years) can be treated with pediatric protocols for osteosarcoma and they experience lower hematologic toxicity compared to pediatric population. Further investigations on sex-related susceptibility to chemotherapy in osteosarcoma patients are recommended.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
