OBJECTIVE: Changes in global temperature are believed to influence fertility. Sperm counts are lowest in summer months and highest in winter. The decrease of birth rate in the last century in all industrialized countries is related to exponential increase of Earth temperature. Very little is kwon about the relationship between global temperature and oocyte development. Several studies in animals showed that IVF achieves better outcomes in cold temperature mainly because hot climates promote oxidative stress which is directly involved in energetic changes and in cellular metabolic homeostasis. DESIGN: The aim of the study is to determine whether seasonal changes of temperature affect follicular recruitment, number of oocytes retrieved and pregnancies achieved in assisted reproduction technology (ART). MATERIALS AND METHODS: IVF cycles performed in Our Centre from 2010 to 2015 were analyzed and divided in two groups according to the month of execution: cold month from December to February (with a mean temperature of 4 C, 39, 2 F) and hot months from june to july (with a mean temperature of 24,4 C, 75, 9 F). All patients underwent ovulation in- duction with recombinant FSH. RESULTS: 1645 cycles were studied, of which 841 in cold months and 804 in hot months. The two groups showed no differences in women age (36 years in cold months vs 36,3 in hot months), ovarian reserve (average FSH and AMH respectively: 8,5 UI/L in cold months vs 8,7 UI/L in hot months and 2,2 ng/ml in cold months and 2,3 ng/ml in hot months) and average number of oocytes retrieved (6 in cold months vs 5,9 in hot months). The study showed no differences also in fertilization rate (75,7% in cold months vs 75,1% in hot months) and pregnancy rate per transfer (29,3% in cold months vs 30,2% in hot months). The abortion rate was respectively 21,7% and 25% in cold and hot months. CONCLUSIONS: Our study showed no significant differences in number of oocytes retrieved and pregnancies achieved. Literature suggests that tem- perature changes can affect natural fertility, but until now no clinical data confirm this influence in IVF treatment
Can global temperature affect in vitro fertilization cycles? / Cipriani, L.; Bianchi, A.; Bazzocchi, A.; Fabbri, F.; Damiano, G.; Ciotti, P.; Notarangelo, L.; Calza, N.; Orazi, L.; Porcu, E.. - In: FERTILITY AND STERILITY. - ISSN 0015-0282. - ELETTRONICO. - 106:3(2016), pp. 286-286. [10.1016/j.fertnstert.2016.07.820]
Can global temperature affect in vitro fertilization cycles?
CIPRIANI, LINDA;BIANCHI, ALICE;BAZZOCCHI, ANTONIA;FABBRI, FEDERICA;DAMIANO, GIUSEPPE;CIOTTI, PATRIZIA;NOTARANGELO, LEONARDO;ORAZI, LUCA;PORCU, ELEONORA
2016
Abstract
OBJECTIVE: Changes in global temperature are believed to influence fertility. Sperm counts are lowest in summer months and highest in winter. The decrease of birth rate in the last century in all industrialized countries is related to exponential increase of Earth temperature. Very little is kwon about the relationship between global temperature and oocyte development. Several studies in animals showed that IVF achieves better outcomes in cold temperature mainly because hot climates promote oxidative stress which is directly involved in energetic changes and in cellular metabolic homeostasis. DESIGN: The aim of the study is to determine whether seasonal changes of temperature affect follicular recruitment, number of oocytes retrieved and pregnancies achieved in assisted reproduction technology (ART). MATERIALS AND METHODS: IVF cycles performed in Our Centre from 2010 to 2015 were analyzed and divided in two groups according to the month of execution: cold month from December to February (with a mean temperature of 4 C, 39, 2 F) and hot months from june to july (with a mean temperature of 24,4 C, 75, 9 F). All patients underwent ovulation in- duction with recombinant FSH. RESULTS: 1645 cycles were studied, of which 841 in cold months and 804 in hot months. The two groups showed no differences in women age (36 years in cold months vs 36,3 in hot months), ovarian reserve (average FSH and AMH respectively: 8,5 UI/L in cold months vs 8,7 UI/L in hot months and 2,2 ng/ml in cold months and 2,3 ng/ml in hot months) and average number of oocytes retrieved (6 in cold months vs 5,9 in hot months). The study showed no differences also in fertilization rate (75,7% in cold months vs 75,1% in hot months) and pregnancy rate per transfer (29,3% in cold months vs 30,2% in hot months). The abortion rate was respectively 21,7% and 25% in cold and hot months. CONCLUSIONS: Our study showed no significant differences in number of oocytes retrieved and pregnancies achieved. Literature suggests that tem- perature changes can affect natural fertility, but until now no clinical data confirm this influence in IVF treatmentI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
