We approach here the problem of defining and estimating the nature of the metabolite-metabolite association network underlying the human individual metabolic phenotype in healthy subjects. We retrieved significant associations using an entropy-based approach and a multiplex network formalism. We defined a significantly over-represented network formed by biologically interpretable metabolite modules. The entropy of the individual metabolic phenotype is also introduced and discussed.

Entropy-Based Network Representation of the Individual Metabolic Phenotype

MENICHETTI, GIULIA;REMONDINI, DANIEL;
2016

Abstract

We approach here the problem of defining and estimating the nature of the metabolite-metabolite association network underlying the human individual metabolic phenotype in healthy subjects. We retrieved significant associations using an entropy-based approach and a multiplex network formalism. We defined a significantly over-represented network formed by biologically interpretable metabolite modules. The entropy of the individual metabolic phenotype is also introduced and discussed.
Saccenti, Edoardo; Menichetti, Giulia; Ghini, Veronica; Remondini, Daniel; Tenori, Leonardo; Luchinat, Claudio
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/598293
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