Down's syndrome (DS) is the most frequent chromosomal aberration in men. Moreover IDS is considered an atheroma-free model. Plasma levels of interleukin-6 (IL-6), tumor necrosis factor-a high sensitivity (hsTNF-alpha), leptin and adiponectin from non-demented DS subjects of three different age cohorts (2-14, 20-50 and above 60 years) and healthy controls were measured. No clinical and sub-clinical inflammation was apparent in DS patients. Plasma levels of hsTNIF-alpha, IL-6 and leptin were higher in children than in adult and old DS subjects. instead, serum levels of adiponectin were increased in older IDS patients than in DS children and adults. High levels of circulating adiponectin might protect DS from clinical complications of atherosclerosis. (C) 2007 Elsevier Ireland Ltd. All rights reserved.
Corsi MM, Dogliotti G, Pedroni F, Galliera E, Malavazos AE, Villa R, et al. (2009). Adipocytokines in Down's syndrome, an atheroma-free model: Role of adiponectin. ARCHIVES OF GERONTOLOGY AND GERIATRICS, 48(1), 106-109 [10.1016/j.archger.2007.10.011].
Adipocytokines in Down's syndrome, an atheroma-free model: Role of adiponectin
CHIAPPELLI, MARTINA;LICASTRO, FEDERICO
2009
Abstract
Down's syndrome (DS) is the most frequent chromosomal aberration in men. Moreover IDS is considered an atheroma-free model. Plasma levels of interleukin-6 (IL-6), tumor necrosis factor-a high sensitivity (hsTNF-alpha), leptin and adiponectin from non-demented DS subjects of three different age cohorts (2-14, 20-50 and above 60 years) and healthy controls were measured. No clinical and sub-clinical inflammation was apparent in DS patients. Plasma levels of hsTNIF-alpha, IL-6 and leptin were higher in children than in adult and old DS subjects. instead, serum levels of adiponectin were increased in older IDS patients than in DS children and adults. High levels of circulating adiponectin might protect DS from clinical complications of atherosclerosis. (C) 2007 Elsevier Ireland Ltd. All rights reserved.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
