Down's syndrome (DS) is the most frequent chromosomal aberration in men. Moreover IDS is considered an atheroma-free model. Plasma levels of interleukin-6 (IL-6), tumor necrosis factor-a high sensitivity (hsTNF-alpha), leptin and adiponectin from non-demented DS subjects of three different age cohorts (2-14, 20-50 and above 60 years) and healthy controls were measured. No clinical and sub-clinical inflammation was apparent in DS patients. Plasma levels of hsTNIF-alpha, IL-6 and leptin were higher in children than in adult and old DS subjects. instead, serum levels of adiponectin were increased in older IDS patients than in DS children and adults. High levels of circulating adiponectin might protect DS from clinical complications of atherosclerosis. (C) 2007 Elsevier Ireland Ltd. All rights reserved.

Adipocytokines in Down's syndrome, an atheroma-free model: Role of adiponectin

CHIAPPELLI, MARTINA;LICASTRO, FEDERICO
2009

Abstract

Down's syndrome (DS) is the most frequent chromosomal aberration in men. Moreover IDS is considered an atheroma-free model. Plasma levels of interleukin-6 (IL-6), tumor necrosis factor-a high sensitivity (hsTNF-alpha), leptin and adiponectin from non-demented DS subjects of three different age cohorts (2-14, 20-50 and above 60 years) and healthy controls were measured. No clinical and sub-clinical inflammation was apparent in DS patients. Plasma levels of hsTNIF-alpha, IL-6 and leptin were higher in children than in adult and old DS subjects. instead, serum levels of adiponectin were increased in older IDS patients than in DS children and adults. High levels of circulating adiponectin might protect DS from clinical complications of atherosclerosis. (C) 2007 Elsevier Ireland Ltd. All rights reserved.
Corsi MM; Dogliotti G; Pedroni F; Galliera E; Malavazos AE; Villa R; Chiappelli M; Licastro F.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11585/59727
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