the presence and inducibility of CYP enzymes belonging to the family 1 (CYP 1A1, 1A2 and 1B!) and AhR have been studied in liver, lung, kidney and heart of control and beta-naphtoflavone (betaNF)-treated pigs. Segments of so far undescribed genes for porcine CYP 1A1, 1A2, 1B1 and Ahr were identified by RT_PCR and their sequences found to be higly homologous to those of the corresponding human genes. Our results demonstrated a differential expression and regulation of the AhR-mediated CYP genes in liver, lung, kidney and heart of the pig-naphtoflavone.
Chirulli V., Marvasi L., Zaghini A., Fiorio R., Longo V., Grvasi P.G. (2007). Inducibility of AhR-regulated CYP genes by beta-naphtoflavone in the liver, lung, kidney and heart of the pig. TOXICOLOGY, 240, 25-37 [10.1016/j.tox.2007.07.015].
Inducibility of AhR-regulated CYP genes by beta-naphtoflavone in the liver, lung, kidney and heart of the pig
MARVASI, LUIGI;ZAGHINI, ANNA;
2007
Abstract
the presence and inducibility of CYP enzymes belonging to the family 1 (CYP 1A1, 1A2 and 1B!) and AhR have been studied in liver, lung, kidney and heart of control and beta-naphtoflavone (betaNF)-treated pigs. Segments of so far undescribed genes for porcine CYP 1A1, 1A2, 1B1 and Ahr were identified by RT_PCR and their sequences found to be higly homologous to those of the corresponding human genes. Our results demonstrated a differential expression and regulation of the AhR-mediated CYP genes in liver, lung, kidney and heart of the pig-naphtoflavone.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
