Background: The Predictive and prognostic role of neuron-specific enolase (NSE) in non-small cell lung cancer (NSCLC) is still under debate. Patients and Methods: To study these aspects, serum NSE was prospectively measured at baseline of first-line chemotherapy treatment and tested for correlation with clinical outcome in 129 advanced NSCLC patients. Results: An objective response was achieved in 2 7 out of 65 (41.5%) patients with NSE <8.6 ng/ml and in 38 out of 64 (59.4%) patients with NSE >= 8.6 ng/ml (p = 0.05). Logistic analysis confirmed the positive association between objective response and NSE values >= 8.6 ng/ml (odds ratio=1.69; 95% confidence interval: 1.09-2.63; p=0.02). Overall median survival was 10.8 months. A statistically significant prognostic effect on survival was found for performance status, stage and response to treatment, but not for baseline NSE value. Conclusion: Based on these data, baseline circulating tumor NSE levels appear to have a weak predictive role, but not a prognostic significance in patients with advanced NSCLC submitted to standard chemotherapy.
Tiseo M, Ardizzoni A, Cafferata MA, Loprevite M, Chiaramondia M, Filiberti R, et al. (2008). Predictive and prognostic significance of neuron-specific enolase (NSE) in non-small cell lung cancer. ANTICANCER RESEARCH, 28(1B), 507-513.
Predictive and prognostic significance of neuron-specific enolase (NSE) in non-small cell lung cancer
ARDIZZONI, ANDREA;
2008
Abstract
Background: The Predictive and prognostic role of neuron-specific enolase (NSE) in non-small cell lung cancer (NSCLC) is still under debate. Patients and Methods: To study these aspects, serum NSE was prospectively measured at baseline of first-line chemotherapy treatment and tested for correlation with clinical outcome in 129 advanced NSCLC patients. Results: An objective response was achieved in 2 7 out of 65 (41.5%) patients with NSE <8.6 ng/ml and in 38 out of 64 (59.4%) patients with NSE >= 8.6 ng/ml (p = 0.05). Logistic analysis confirmed the positive association between objective response and NSE values >= 8.6 ng/ml (odds ratio=1.69; 95% confidence interval: 1.09-2.63; p=0.02). Overall median survival was 10.8 months. A statistically significant prognostic effect on survival was found for performance status, stage and response to treatment, but not for baseline NSE value. Conclusion: Based on these data, baseline circulating tumor NSE levels appear to have a weak predictive role, but not a prognostic significance in patients with advanced NSCLC submitted to standard chemotherapy.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
