Background: Epidermal growth factor receptor (EGFR) gene copy number has been proposed as predictor of response to epidermal growth factor receptor tyrosine kinase inhibitors in advanced non-small cell lung cancer (NSCLC). Methods: Cytologic and matched histologic samples from 33 primary non-small cell lung cancers were analyzed by fluorescence in situ hybridization (FISH) for epidermal growth factor receptor gene. Results: FISH was positive in 52% and negative in 35% of the 31 matched evaluable samples. Four of 31 (13%) cases were discordant (K = 0.736; p <0.001). Conclusion: Our data support the feasibility and reliability of epidermal growth factor receptor gene assessment by FISH on cytology.
Is Cytology Reliable for Epidermal Growth Factor Receptor Gene Evaluation in Non-small Cell Lung Cancer? / Bozzetti C; Tiseo M; Lagrasta C; Nizzoli R; Guazzi A; Graiani G; Rindi G; Ardizzoni A. - In: JOURNAL OF THORACIC ONCOLOGY. - ISSN 1556-0864. - ELETTRONICO. - 5:4(2010), pp. 551-553. [10.1097/JTO.0b013e3181ce3b28]
Is Cytology Reliable for Epidermal Growth Factor Receptor Gene Evaluation in Non-small Cell Lung Cancer?
ARDIZZONI, ANDREA
2010
Abstract
Background: Epidermal growth factor receptor (EGFR) gene copy number has been proposed as predictor of response to epidermal growth factor receptor tyrosine kinase inhibitors in advanced non-small cell lung cancer (NSCLC). Methods: Cytologic and matched histologic samples from 33 primary non-small cell lung cancers were analyzed by fluorescence in situ hybridization (FISH) for epidermal growth factor receptor gene. Results: FISH was positive in 52% and negative in 35% of the 31 matched evaluable samples. Four of 31 (13%) cases were discordant (K = 0.736; p <0.001). Conclusion: Our data support the feasibility and reliability of epidermal growth factor receptor gene assessment by FISH on cytology.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
