Background: Human leishmaniasis is on increase in the Mediterranean Europe. However, the exact prevalence of cutaneous leishmaniasis (CL) is largely unknown as underdiagnosis and under reporting are common. Objective: To evaluate epidemiological, clinicopathological and microbiological aspects of CL cases occurring in the Bologna Province, north-eastern Italy. Methods: We performed a retrospective, observational study on CL cases diagnosed in the Bologna Province between January 2013 and December 2015. Results: During 2013–2015, 30 cases of CL were identified in the Bologna Province with an average incidence of 1.00/100 000, with an increase of fourfold to 12-fold as compared to previous years. 16 of 30 (53%) CL cases presented as single, typical lesions. CL diagnosis was carried out by histological and molecular techniques, although in 7 of 29 (24%) PCR-positive cases, amastigotes were not visible on histology. Conclusions: We report new evidence of CL cases in a focal area of north-eastern Italy in 2013–2015. Our study highlights the importance of CL surveillance in the Mediterranean basin and emphasizes the need for the molecular laboratory surveillance of CL in endemic areas.

Gaspari, V., Ortalli, M., Foschini, M.P., Baldovini, C., Lanzoni, A., Cagarelli, R., et al. (2017). New evidence of cutaneous leishmaniasis in north-eastern Italy. JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, 31(9), 1534-1540 [10.1111/jdv.14309].

New evidence of cutaneous leishmaniasis in north-eastern Italy

Gaspari, Valeria;Ortalli, Margherita;Foschini, Maria Pia;Baldovini, Chiara;Lanzoni, Angela;Gaibani, Paolo;Rossini, Giada;Vocale, Caterina;Gentilomi, G. A;Misciali, Cosimo;Pesci, Silvia;Patrizi, Annalisa;Landini, M. P;Varani, Stefania
2017

Abstract

Background: Human leishmaniasis is on increase in the Mediterranean Europe. However, the exact prevalence of cutaneous leishmaniasis (CL) is largely unknown as underdiagnosis and under reporting are common. Objective: To evaluate epidemiological, clinicopathological and microbiological aspects of CL cases occurring in the Bologna Province, north-eastern Italy. Methods: We performed a retrospective, observational study on CL cases diagnosed in the Bologna Province between January 2013 and December 2015. Results: During 2013–2015, 30 cases of CL were identified in the Bologna Province with an average incidence of 1.00/100 000, with an increase of fourfold to 12-fold as compared to previous years. 16 of 30 (53%) CL cases presented as single, typical lesions. CL diagnosis was carried out by histological and molecular techniques, although in 7 of 29 (24%) PCR-positive cases, amastigotes were not visible on histology. Conclusions: We report new evidence of CL cases in a focal area of north-eastern Italy in 2013–2015. Our study highlights the importance of CL surveillance in the Mediterranean basin and emphasizes the need for the molecular laboratory surveillance of CL in endemic areas.
2017
Gaspari, V., Ortalli, M., Foschini, M.P., Baldovini, C., Lanzoni, A., Cagarelli, R., et al. (2017). New evidence of cutaneous leishmaniasis in north-eastern Italy. JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, 31(9), 1534-1540 [10.1111/jdv.14309].
Gaspari, Valeria; Ortalli, Margherita; Foschini, Maria Pia; Baldovini, Chiara; Lanzoni, Angela; Cagarelli, R; Gaibani, Paolo; Rossini, Giada; Vocale, ...espandi
File in questo prodotto:
File Dimensione Formato  
JEADV_UNIBO_postprint_IRIS(1).pdf

Open Access dal 01/10/2018

Descrizione: Accepted manuscript
Tipo: Postprint
Licenza: Licenza per accesso libero gratuito
Dimensione 1.72 MB
Formato Adobe PDF
1.72 MB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/590121
Citazioni
  • ???jsp.display-item.citation.pmc??? 10
  • Scopus 17
  • ???jsp.display-item.citation.isi??? 20
social impact