Epidermal Growth Factor Receptor (EGFR) molecular analysis is performed to assess the responsiveness to Tyrosine Kinase Inhibitors (TKIs) in patients with Non-Small Cell Lung Cancer (NSCLC). The existence of molecular intra-tumoral heterogeneity has been observed in lung cancers. The aim of the present study is to investigate if the percentage of mutated neoplastic cells within the tumor sample might influence the responsiveness to TKIs treatment.
The percentage of Epidermal Growth Factor Receptor (EGFR)-mutated neoplastic cells correlates to response to tyrosine kinase inhibitors in lung adenocarcinoma / de Biase, Dario; Genestreti, Giovenzio; Visani, Michela; Acquaviva, Giorgia; Di Battista, Monica; Cavallo, Giovanna; Paccapelo, Alexandro; Cancellieri, Alessandra; Trisolini, Rocco; Degli Esposti, Roberta; Bartolini, Stefania; Pession, Annalisa; Tallini, Giovanni; Brandes, Alba A. - In: PLOS ONE. - ISSN 1932-6203. - ELETTRONICO. - 12:5(2017), pp. e0177822.1-e0177822.13. [10.1371/journal.pone.0177822]
The percentage of Epidermal Growth Factor Receptor (EGFR)-mutated neoplastic cells correlates to response to tyrosine kinase inhibitors in lung adenocarcinoma
DE BIASE, DARIO;VISANI, MICHELA;ACQUAVIVA, GIORGIA;PESSION, ANNALISA;TALLINI, GIOVANNI;
2017
Abstract
Epidermal Growth Factor Receptor (EGFR) molecular analysis is performed to assess the responsiveness to Tyrosine Kinase Inhibitors (TKIs) in patients with Non-Small Cell Lung Cancer (NSCLC). The existence of molecular intra-tumoral heterogeneity has been observed in lung cancers. The aim of the present study is to investigate if the percentage of mutated neoplastic cells within the tumor sample might influence the responsiveness to TKIs treatment.| File | Dimensione | Formato | |
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