The aim of the present study was to investigate outcomes of implantable cardioverter-defibrillator (ICD) treatment in patients with arrhythmogenic right ventricular cardiomyopathy (ARVC). We reviewed baseline/follow-up data of 15 consecutive ARVC patients (mean age 55 +/- 15 years) and 30 randomly drawn patients with coronary artery disease (CAD) (mean age 60 +/- 10 years) with matching durations of follow-up (all implanted with ICDs for primary/secondary prevention of sudden death). At implant, appropriate placement of the RV lead was more difficult in ARVC patients. During follow-up (median 41 months), appropriate interventions for any ventricular tachyarrhythmias occurred in 8 (53%) ARVC patients and 17 (57%) CAD patients, but the occurrence of high rate (>240 beats/min) ventricular tachyarrhythmias was higher in ARVC patients. Inappropriate ICD interventions occurred in 5 (33%) ARVC patients and 10 (33%) CAD patients. Lead-related adverse events requiring surgical revision occurred in 7 (47%) ARVC patients as compared with 4 (13%) CAD patients (P = 0.0004). While ICD implantation is highly effective for prevention of sudden death in ARVC, it does carry elevated burdens of long-term lead-related adverse events. These findings underline the need of careful follow-up in ARVC aimed at early recognition of complications that can impair ICD function.

Outcome of cardioverter-defibrillator implant in patients with arrhythmogenic right ventricular cardiomyopathy / G. Boriani; P. Artale; M. Biffi; C. Martignani; L. Frabetti; C. Valzania; I. Diemberger; M. Ziacchi; M. Bertini; C. Rapezzi; M. Parlapiano; A. Branzi. - In: HEART AND VESSELS. - ISSN 0910-8327. - ELETTRONICO. - 22 (3):(2007), pp. 184-192. [10.1007/s00380-006-0963-8]

Outcome of cardioverter-defibrillator implant in patients with arrhythmogenic right ventricular cardiomyopathy.

BORIANI, GIUSEPPE;BIFFI, MAURO;MARTIGNANI, CRISTIAN;FRABETTI, LORENZO;VALZANIA, CINZIA;DIEMBERGER, IGOR;ZIACCHI, MATTEO;BERTINI, MATTEO;RAPEZZI, CLAUDIO;PARLAPIANO, MARIO NICOLA;BRANZI, ANGELO
2007

Abstract

The aim of the present study was to investigate outcomes of implantable cardioverter-defibrillator (ICD) treatment in patients with arrhythmogenic right ventricular cardiomyopathy (ARVC). We reviewed baseline/follow-up data of 15 consecutive ARVC patients (mean age 55 +/- 15 years) and 30 randomly drawn patients with coronary artery disease (CAD) (mean age 60 +/- 10 years) with matching durations of follow-up (all implanted with ICDs for primary/secondary prevention of sudden death). At implant, appropriate placement of the RV lead was more difficult in ARVC patients. During follow-up (median 41 months), appropriate interventions for any ventricular tachyarrhythmias occurred in 8 (53%) ARVC patients and 17 (57%) CAD patients, but the occurrence of high rate (>240 beats/min) ventricular tachyarrhythmias was higher in ARVC patients. Inappropriate ICD interventions occurred in 5 (33%) ARVC patients and 10 (33%) CAD patients. Lead-related adverse events requiring surgical revision occurred in 7 (47%) ARVC patients as compared with 4 (13%) CAD patients (P = 0.0004). While ICD implantation is highly effective for prevention of sudden death in ARVC, it does carry elevated burdens of long-term lead-related adverse events. These findings underline the need of careful follow-up in ARVC aimed at early recognition of complications that can impair ICD function.
2007
Outcome of cardioverter-defibrillator implant in patients with arrhythmogenic right ventricular cardiomyopathy / G. Boriani; P. Artale; M. Biffi; C. Martignani; L. Frabetti; C. Valzania; I. Diemberger; M. Ziacchi; M. Bertini; C. Rapezzi; M. Parlapiano; A. Branzi. - In: HEART AND VESSELS. - ISSN 0910-8327. - ELETTRONICO. - 22 (3):(2007), pp. 184-192. [10.1007/s00380-006-0963-8]
G. Boriani; P. Artale; M. Biffi; C. Martignani; L. Frabetti; C. Valzania; I. Diemberger; M. Ziacchi; M. Bertini; C. Rapezzi; M. Parlapiano; A. Branzi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/58858
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