Neuroactive steroids may play a role in the pathophysiology of psychotic disorders, but few studies examined this issue. We compared serum levels of cortisol, testosterone, dehydroepiandrosterone, and progesterone between a representative sample of first-episode psychosis (FEP) patients and age- and gender-matched healthy subjects. Furthermore, we analyzed the associations between neuroactive steroids levels and the severity of psychotic symptom dimensions. Male patients had lower levels of progesterone than controls (p = 0.03). Progesterone levels were inversely associated with the severity of positive symptoms (p = 0.007). Consistent with preclinical findings, results suggest that progesterone might have a role in the pathophysiology of psychotic disorders.
Belvederi Murri, M., Fanelli, F., Pagotto, U., Bonora, E., Triolo, F., Chiri, L., et al. (2016). Neuroactive Steroids in First-Episode Psychosis: A Role for Progesterone?. SCHIZOPHRENIA RESEARCH AND TREATMENT, 2016, 1-6 [10.1155/2016/1942828].
Neuroactive Steroids in First-Episode Psychosis: A Role for Progesterone?
FANELLI, FLAMINIA;PAGOTTO, UBERTO;BONORA, ELENA;TRIOLO, FEDERICO;CHIRI, LUIGI ROCCO;MEZZULLO, MARCO;MENCHETTI, MARCO;BERARDI, DOMENICO;TARRICONE, ILARIA
2016
Abstract
Neuroactive steroids may play a role in the pathophysiology of psychotic disorders, but few studies examined this issue. We compared serum levels of cortisol, testosterone, dehydroepiandrosterone, and progesterone between a representative sample of first-episode psychosis (FEP) patients and age- and gender-matched healthy subjects. Furthermore, we analyzed the associations between neuroactive steroids levels and the severity of psychotic symptom dimensions. Male patients had lower levels of progesterone than controls (p = 0.03). Progesterone levels were inversely associated with the severity of positive symptoms (p = 0.007). Consistent with preclinical findings, results suggest that progesterone might have a role in the pathophysiology of psychotic disorders.File | Dimensione | Formato | |
---|---|---|---|
Belvederi Murri 2016.pdf
accesso aperto
Descrizione: Belvederi Murri et al., 2016
Tipo:
Versione (PDF) editoriale
Licenza:
Licenza per Accesso Aperto. Creative Commons Attribuzione (CCBY)
Dimensione
1.19 MB
Formato
Adobe PDF
|
1.19 MB | Adobe PDF | Visualizza/Apri |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.