Introduction: Nuclear inositide signaling pathways specifically regulate cell proliferation and differentiation. Interestingly, the modulation of nuclear inositides in hematological malignancies can differentially affect erythropoiesis or myelopoiesis. This is particularly important in patients with myelodysplastic syndromes (MDS), who show both defective erythroid and myeloid differentiation, as well as an increased risk of evolution into acute myeloid leukemia (AML). Areas covered: This review focuses on the structure and function of specific nuclear inositide enzymes, whose impairment could be linked with disease pathogenesis and cancer. The authors, stemming from literature and published data, discuss and describe the role of nuclear inositides, focusing on specific enzymes and demonstrating that targeting these molecules could be important to develop innovative therapeutic approaches, with particular reference to MDS treatment. Expert opinion: Demethylating therapy, alone or in combination with other drugs, is the most common and current therapy for MDS patients. Nuclear inositide signaling molecules have been demonstrated to be important in hematopoietic differentiation and are promising new targets for developing a personalized MDS therapy. Indeed, these enzymes can be ideal targets for drug design and their modulation can have several important downstream effects to regulate MDS pathogenesis and prevent MDS progression to AML.

Mongiorgi, S., Finelli, C., Yang, Y.R., Clissa, C., Mccubrey, J.A., Billi, A.M., et al. (2016). Inositide-dependent signaling pathways as new therapeutic targets in myelodysplastic syndromes. EXPERT OPINION ON THERAPEUTIC TARGETS, 20(6), 677-687 [10.1517/14728222.2016.1125885].

Inositide-dependent signaling pathways as new therapeutic targets in myelodysplastic syndromes

MONGIORGI, SARA;FINELLI, CARLO;CLISSA, CRISTINA;BILLI, ANNA MARIA;MANZOLI, LUCIA;COCCO, LUCIO ILDEBRANDO;FOLLO, MATILDE YUNG
2016

Abstract

Introduction: Nuclear inositide signaling pathways specifically regulate cell proliferation and differentiation. Interestingly, the modulation of nuclear inositides in hematological malignancies can differentially affect erythropoiesis or myelopoiesis. This is particularly important in patients with myelodysplastic syndromes (MDS), who show both defective erythroid and myeloid differentiation, as well as an increased risk of evolution into acute myeloid leukemia (AML). Areas covered: This review focuses on the structure and function of specific nuclear inositide enzymes, whose impairment could be linked with disease pathogenesis and cancer. The authors, stemming from literature and published data, discuss and describe the role of nuclear inositides, focusing on specific enzymes and demonstrating that targeting these molecules could be important to develop innovative therapeutic approaches, with particular reference to MDS treatment. Expert opinion: Demethylating therapy, alone or in combination with other drugs, is the most common and current therapy for MDS patients. Nuclear inositide signaling molecules have been demonstrated to be important in hematopoietic differentiation and are promising new targets for developing a personalized MDS therapy. Indeed, these enzymes can be ideal targets for drug design and their modulation can have several important downstream effects to regulate MDS pathogenesis and prevent MDS progression to AML.
2016
Mongiorgi, S., Finelli, C., Yang, Y.R., Clissa, C., Mccubrey, J.A., Billi, A.M., et al. (2016). Inositide-dependent signaling pathways as new therapeutic targets in myelodysplastic syndromes. EXPERT OPINION ON THERAPEUTIC TARGETS, 20(6), 677-687 [10.1517/14728222.2016.1125885].
Mongiorgi, Sara; Finelli, Carlo; Yang, Yong Ryoul; Clissa, Cristina; Mccubrey, James A.; Billi, Anna Maria; Manzoli, Lucia; Suh, Pann-Ghill; Cocco, Lu...espandi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/587112
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