In human ribosomal RNAs, over 200 residues are modified by specific, RNA-driven enzymatic complexes or stand-alone, RNA-independent enzymes. In most cases, modification sites are placed in specific positions within important functional areas of the ribosome. Some evidence indicates that the altered control in ribosomal RNA modifications may affect ribosomal function during mRNA translation. Here we provide an overview of the connections linking ribosomal RNA modifications to ribosome function, and suggest how aberrant modifications may affect the control of the expression of key cancer genes, thus contributing to tumor development. In addition, the future perspectives in this field are discussed.
Penzo, M., Galbiati, A., Treré, D., Montanaro, L. (2016). The importance of being (slightly) modified: The role of rRNA editing on gene expression control and its connections with cancer. BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 1866(2), 330-338 [10.1016/j.bbcan.2016.10.007].
The importance of being (slightly) modified: The role of rRNA editing on gene expression control and its connections with cancer
PENZO, MARIANNA;GALBIATI, ALICE;TRERE', DAVIDE;MONTANARO, LORENZO
2016
Abstract
In human ribosomal RNAs, over 200 residues are modified by specific, RNA-driven enzymatic complexes or stand-alone, RNA-independent enzymes. In most cases, modification sites are placed in specific positions within important functional areas of the ribosome. Some evidence indicates that the altered control in ribosomal RNA modifications may affect ribosomal function during mRNA translation. Here we provide an overview of the connections linking ribosomal RNA modifications to ribosome function, and suggest how aberrant modifications may affect the control of the expression of key cancer genes, thus contributing to tumor development. In addition, the future perspectives in this field are discussed.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
