In recent years, the increase of migration from countries where human immunodeficiency virus type 2 (HIV-2) is endemic to industrialized countries has facilitated the spread of the virus in individuals previously unexposed to this threat. In this report, we performed a phylogenetic analysis on pol and env sequences of HIV-2 strains identified in foreigners and native citizens to trace the origin of infection. All but one of the 17 pol gene sequences were classified as group A. HIV-2 strains were aggregated in several clusters depending by the country of origin and/or infection. One patient (1AA) was classified as being infected with a recombinant between HIV-2 group A and HIV-2 group B, because the pol gene sequence was clearly in the group A, but an env V3 region sequence from this patient was more similar to group B viruses. Therefore, it is urgent to strengthen the surveillance and use adequate molecular virological tools to diagnose and monitor HIV-2 infection. © Mary Ann Liebert, Inc.

D'Ettorre, G., Lo Presti, A., Gori, C., Cella, E., Bertoli, A., Vullo, V., et al. (2013). An HIV type 2 case series in Italy: A phylogenetic analysis. AIDS RESEARCH AND HUMAN RETROVIRUSES, 29(9), 1254-1259 [10.1089/aid.2013.0091].

An HIV type 2 case series in Italy: A phylogenetic analysis

BON, ISABELLA;
2013

Abstract

In recent years, the increase of migration from countries where human immunodeficiency virus type 2 (HIV-2) is endemic to industrialized countries has facilitated the spread of the virus in individuals previously unexposed to this threat. In this report, we performed a phylogenetic analysis on pol and env sequences of HIV-2 strains identified in foreigners and native citizens to trace the origin of infection. All but one of the 17 pol gene sequences were classified as group A. HIV-2 strains were aggregated in several clusters depending by the country of origin and/or infection. One patient (1AA) was classified as being infected with a recombinant between HIV-2 group A and HIV-2 group B, because the pol gene sequence was clearly in the group A, but an env V3 region sequence from this patient was more similar to group B viruses. Therefore, it is urgent to strengthen the surveillance and use adequate molecular virological tools to diagnose and monitor HIV-2 infection. © Mary Ann Liebert, Inc.
2013
D'Ettorre, G., Lo Presti, A., Gori, C., Cella, E., Bertoli, A., Vullo, V., et al. (2013). An HIV type 2 case series in Italy: A phylogenetic analysis. AIDS RESEARCH AND HUMAN RETROVIRUSES, 29(9), 1254-1259 [10.1089/aid.2013.0091].
D'Ettorre, Gabriella; Lo Presti, Alessandra; Gori, Caterina; Cella, Eleonora; Bertoli, Ada; Vullo, Vincenzo; Perno, Carlo Federico; Ciotti, Marco; Fol...espandi
File in questo prodotto:
Eventuali allegati, non sono esposti

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/585637
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 1
  • Scopus 6
  • ???jsp.display-item.citation.isi??? 4
social impact