G-protein coupled receptors (GPCRs) constitute the targets of about 40 % of all the pharmaceutical drugs in the market and, among other functions, a large portion of the family detects odorants and a variety of tastant molecules. Computational techniques are instrumental to understand structure, dynamics and function of the cascades triggered by these receptors. As an example, here we report our own computational work aimed to dissect GPCR molecular mechanisms for chemical senses. The implications of our work for systems biology and for pharmacology are discussed. © Springer International Publishing Switzerland 2014.

Chemosensorial G-proteins-coupled receptors: A perspective from computational methods

MUSIANI, FRANCESCO;
2014

Abstract

G-protein coupled receptors (GPCRs) constitute the targets of about 40 % of all the pharmaceutical drugs in the market and, among other functions, a large portion of the family detects odorants and a variety of tastant molecules. Computational techniques are instrumental to understand structure, dynamics and function of the cascades triggered by these receptors. As an example, here we report our own computational work aimed to dissect GPCR molecular mechanisms for chemical senses. The implications of our work for systems biology and for pharmacology are discussed. © Springer International Publishing Switzerland 2014.
Advances in Experimental Medicine and Biology
441
457
Musiani, Francesco; Rossetti, Giulia; Giorgetti, Alejandro; Carloni, Paolo
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/585362
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