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EnglishCastanea sativa Mill (ENC®), containing tannins against 33 Chlamydia strains, was compared to SMAP-29 with inhibitory effect against C. trachomatis and C. pneumoniae. The ENC® activity against Chlamydia spp. was evaluated determining the lowest concentration to achieve more than half reduction of intact chlamydial inclusions versus controls. ENC® reduced all Chlamydia strains tested at 1 µg/mL, while SMAP-29 induced reductions of C. trachomatis and C. pneumoniae infectivity at 10 µg/mL. A great reduction of C. trachomatis, C. pneumoniae, and C. abortus infectivity was achieved with a 10 µg/mL ENC® concentration, whereas their infectivity was almost inhibited at 100 µg/mL ENC® concentration.
| Titolo: | In vitro activity of a partially purified and characterized bark extract of Castanea sativa Mill. (ENC®) against Chlamydia spp |
| Autore/i: | PAPA, VALENTINA; GINOCCHIETTI, LAURA; BUDRIESI, ROBERTA; MICUCCI, MATTEO; COSTA, ROBERTA; BIONDI, ROBERTA; CEVENINI, ROBERTO; CHIARINI, ALBERTO; ALDINI, RITA; DONATI, MANUELA; POLLINI, GIAN MATTEO; CENACCHI, GIOVANNA |
| Autore/i Unibo: | |
| Anno: | 2017 |
| Rivista: | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1080/01913123.2016.1275909 |
| Abstract: | Castanea sativa Mill (ENC®), containing tannins against 33 Chlamydia strains, was compared to SMAP-29 with inhibitory effect against C. trachomatis and C. pneumoniae. The ENC® activity against Chlamydia spp. was evaluated determining the lowest concentration to achieve more than half reduction of intact chlamydial inclusions versus controls. ENC® reduced all Chlamydia strains tested at 1 µg/mL, while SMAP-29 induced reductions of C. trachomatis and C. pneumoniae infectivity at 10 µg/mL. A great reduction of C. trachomatis, C. pneumoniae, and C. abortus infectivity was achieved with a 10 µg/mL ENC® concentration, whereas their infectivity was almost inhibited at 100 µg/mL ENC® concentration. |
| Data stato definitivo: | 2017-03-30T13:16:57Z |
| Appare nelle tipologie: | 1.01 Articolo in rivista |
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