The association among single nucleotide polymorphisms in inflammatory genes as interleukin-1 alpha (IL-1α), interleukin-1 beta (IL-1β) or tumor necrosis factor alpha (TNF-α) and dementia has been explored mostly in Alzheimer's disease, while few data addressing their association with dementia in very old people are available. We performed a prospective, door-to-door population-based study of 80 years or older residents in eight municipalities of Varese province, Italy (the Monzino 80-plus study). No difference was found by a cross-sectional approach comparing IL-1α rs1800587, IL-1β rs3087258 and TNF-α rs1799724 genotypic and allelic frequencies between those affected and not affected by dementia. After a 5-year follow-up, the elderly carriers of T-allele of TNF-α rs1799724 were at an increased risk of dementia (p=0.03). This association was no more significant adjusting for the apolipoprotein E epsilon-4 allele (APOE-ε4, p=0.26), which was an independent predictor of dementia onset (p=0.0002). In short, in this Italian population of oldest olds, dementia was associated to the APOE-ε4 allele only. © 2011 American Aging Association.
Albani, D., Tettamanti, M., Batelli, S., Polito, L., Dusi, S., Ateri, E., et al. (2012). Interleukin-1α, interleukin-1β and tumor necrosis factor-α genetic variants and risk of dementia in the very old: Evidence from the "monzino 80-plus" prospective study. AGE, 34(2), 519-526 [10.1007/s11357-011-9249-x].
Interleukin-1α, interleukin-1β and tumor necrosis factor-α genetic variants and risk of dementia in the very old: Evidence from the "monzino 80-plus" prospective study
DUSI, SABRINA;
2012
Abstract
The association among single nucleotide polymorphisms in inflammatory genes as interleukin-1 alpha (IL-1α), interleukin-1 beta (IL-1β) or tumor necrosis factor alpha (TNF-α) and dementia has been explored mostly in Alzheimer's disease, while few data addressing their association with dementia in very old people are available. We performed a prospective, door-to-door population-based study of 80 years or older residents in eight municipalities of Varese province, Italy (the Monzino 80-plus study). No difference was found by a cross-sectional approach comparing IL-1α rs1800587, IL-1β rs3087258 and TNF-α rs1799724 genotypic and allelic frequencies between those affected and not affected by dementia. After a 5-year follow-up, the elderly carriers of T-allele of TNF-α rs1799724 were at an increased risk of dementia (p=0.03). This association was no more significant adjusting for the apolipoprotein E epsilon-4 allele (APOE-ε4, p=0.26), which was an independent predictor of dementia onset (p=0.0002). In short, in this Italian population of oldest olds, dementia was associated to the APOE-ε4 allele only. © 2011 American Aging Association.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.