Neoadjuvant concomitant chemoradiotherapy has become a standard treatment of locally advanced rectal adenocarcinomas (LARA). It can reduce tumor volume, thus increases a feasibility of sphincter-sparing surgery, shows less acute toxicity, improves local control rate. It is based on fluoropyrimidines (5-fluorouracil, capecitabine) with concurrent radiotherapy. The aim of the study was to evaluate the capability of gene expression method to identify nonresponders (NR) pretherapeutically.

Garajová, I., Slabý, O., Svoboda, M., Fabian, P., Silák, J., Smerdová, T., et al. (2008). [Gene expression profiling in prediction of tumor response to neoadjuvant concomitant chemoradiotherapy in patients with locally advanced rectal carcinoma: pilot study]. CASOPIS LEKARU CESKYCH, 147(7), 381-386.

[Gene expression profiling in prediction of tumor response to neoadjuvant concomitant chemoradiotherapy in patients with locally advanced rectal carcinoma: pilot study]

GARAJOVA, INGRID;
2008

Abstract

Neoadjuvant concomitant chemoradiotherapy has become a standard treatment of locally advanced rectal adenocarcinomas (LARA). It can reduce tumor volume, thus increases a feasibility of sphincter-sparing surgery, shows less acute toxicity, improves local control rate. It is based on fluoropyrimidines (5-fluorouracil, capecitabine) with concurrent radiotherapy. The aim of the study was to evaluate the capability of gene expression method to identify nonresponders (NR) pretherapeutically.
2008
Garajová, I., Slabý, O., Svoboda, M., Fabian, P., Silák, J., Smerdová, T., et al. (2008). [Gene expression profiling in prediction of tumor response to neoadjuvant concomitant chemoradiotherapy in patients with locally advanced rectal carcinoma: pilot study]. CASOPIS LEKARU CESKYCH, 147(7), 381-386.
Garajová, I; Slabý, O; Svoboda, M; Fabian, P; Silák, J; Smerdová, T; Kocák, I; Růzicková, J; Hoch, J; Vyzula, R...espandi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/580610
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