Therapeutic advancements following the introduction of autologous stem cell transplantation and 'novel' agents have significantly improved clinical outcomes for patients with multiple myeloma (MM). Increased life expectancy, however, has led to renewed concerns about the long-term risk of second primary malignancies (SPMs). This review outlines the most up-to-date knowledge of possible host-, disease-, and treatment-related risk factors for the development of SPMs in patients with MM, and provides practical recommendations to assist physicians.
Second primary malignancies in multiple myeloma: an overview and IMWG consensus / Musto, P; Anderson, K C; Attal, M; Richardson, P G; Badros, A; Hou, J; Comenzo, R; Du, J; Durie, B G M; San Miguel, J; Einsele, H; Chen, W M; Garderet, L; Pietrantuono, G; Hillengass, J; Kyle, R A; Moreau, P; Lahuerta, J J; Landgren, O; Ludwig, H; Larocca, A; Mahindra, A; Cavo, M; Mazumder, A; Mccarthy, P L; Nouel, A; Rajkumar, S V; Reiman, A; Serra, E R; Sezer, O; Terpos, E; Turesson, I; Usmani, S; Weiss, B M; Palumbo, A. - In: ANNALS OF ONCOLOGY. - ISSN 0923-7534. - ELETTRONICO. - 28:2(2017), pp. 228-245. [10.1093/annonc/mdw606]
Second primary malignancies in multiple myeloma: an overview and IMWG consensus
CAVO, MICHELE;
2017
Abstract
Therapeutic advancements following the introduction of autologous stem cell transplantation and 'novel' agents have significantly improved clinical outcomes for patients with multiple myeloma (MM). Increased life expectancy, however, has led to renewed concerns about the long-term risk of second primary malignancies (SPMs). This review outlines the most up-to-date knowledge of possible host-, disease-, and treatment-related risk factors for the development of SPMs in patients with MM, and provides practical recommendations to assist physicians.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.