PI-PLCbeta1 plays an important role in cell differentiation, and particularly in myogenesis, osteogenesis and hematopoiesis. Indeed, the increase of PI-PLCbeta1, along with Cyclin D3, has been detected in C2C12 mouse myoblasts induced to differentiate, as well as in human cells obtained from myotonic dystrophy. Also in the case of osteogenic differentiation there is a specific induction of PI-PLCbeta1, but in this case the role of PI-PLCbeta1 seems to be independent from Cyclin D3, so that a different mechanism could be involved. As for the hematopoietic system, PI-PLCbeta1 has a peculiar behavior: it increases during myeloid differentiation and decreases during erythroid differentiation, thus confirming the role of PI-PLCbeta1 as a modulator of hematopoiesis.
Modulation of nuclear PI-PLCbeta1 during cell differentiation / Cocco, Lucio; Manzoli, Lucia; Faenza, Irene; Ramazzotti, Giulia; Yang, Yong Ryoul; Mccubrey, James A.; Suh, Pann-Ghill; Follo, Matilde Y. - In: ADVANCES IN BIOLOGICAL REGULATION. - ISSN 2212-4926. - ELETTRONICO. - 60:(2016), pp. 1-5. [10.1016/j.jbior.2015.10.008]
Modulation of nuclear PI-PLCbeta1 during cell differentiation
COCCO, LUCIO ILDEBRANDO;MANZOLI, LUCIA;FAENZA, IRENE;RAMAZZOTTI, GIULIA;FOLLO, MATILDE YUNG
2016
Abstract
PI-PLCbeta1 plays an important role in cell differentiation, and particularly in myogenesis, osteogenesis and hematopoiesis. Indeed, the increase of PI-PLCbeta1, along with Cyclin D3, has been detected in C2C12 mouse myoblasts induced to differentiate, as well as in human cells obtained from myotonic dystrophy. Also in the case of osteogenic differentiation there is a specific induction of PI-PLCbeta1, but in this case the role of PI-PLCbeta1 seems to be independent from Cyclin D3, so that a different mechanism could be involved. As for the hematopoietic system, PI-PLCbeta1 has a peculiar behavior: it increases during myeloid differentiation and decreases during erythroid differentiation, thus confirming the role of PI-PLCbeta1 as a modulator of hematopoiesis.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
