Phosphoinositide-phospholipase C-β1 (PLC-β1) plays a crucial role in the initiation of the genetic program responsible for muscle differentiation and osteogenesis. During myogenic differentiation of murine C2C12 myoblasts, PLC-β1 signaling pathway involves the Inositol Polyphosphate Multikinase (IPMK) and β-catenin as downstream effectors. By means of c-jun binding to cyclin D3 promoter, the activation of PLC-β1 pathway determines cyclin D3 accumulation. However, osteogenesis requires PLC-β1 expression and up-regulation but it does not affect cyclin D3 levels, suggesting that the two processes require the activation of different mediators.
Ramazzotti, G., Faenza, I., Fiume, R., Billi, A.M., Manzoli, L., Mongiorgi, S., et al. (2017). PLC-β1 and cell differentiation: An insight into myogenesis and osteogenesis. ADVANCES IN BIOLOGICAL REGULATION, 63, 1-5 [10.1016/j.jbior.2016.10.005].
PLC-β1 and cell differentiation: An insight into myogenesis and osteogenesis
RAMAZZOTTI, GIULIA;FAENZA, IRENE;FIUME, ROBERTA;BILLI, ANNA MARIA;MANZOLI, LUCIA;MONGIORGI, SARA;RATTI, STEFANO;COCCO, LUCIO ILDEBRANDO;FOLLO, MATILDE YUNG
2017
Abstract
Phosphoinositide-phospholipase C-β1 (PLC-β1) plays a crucial role in the initiation of the genetic program responsible for muscle differentiation and osteogenesis. During myogenic differentiation of murine C2C12 myoblasts, PLC-β1 signaling pathway involves the Inositol Polyphosphate Multikinase (IPMK) and β-catenin as downstream effectors. By means of c-jun binding to cyclin D3 promoter, the activation of PLC-β1 pathway determines cyclin D3 accumulation. However, osteogenesis requires PLC-β1 expression and up-regulation but it does not affect cyclin D3 levels, suggesting that the two processes require the activation of different mediators.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
