Abstract: Electrophysiological investigations of restless legs syndrome (RLS) have found spinal circuits impinging on motoneurones. We evaluated the H reflex threshold, latency, the Hmax/Mmax ratio, and the short latency autogenic inhibition in 7 patients with RLS and 10 age-matched controls by testing the excitability changes in soleus H reflex Ib interneuron function. A significant reduction in Ib inhibition at 4 (P 0.043), 5 (P 0.007), and 6 ms (P 0.001) of H reflex conditioning interstimulus interval was found in RLS patients. Data support the hypothesis that altered group I nonreciprocal inhibition is implicated in enhancing the spinal circuitry excitability of RLS, and are consistent with the view of an abnormal supraspinal drive to spinal interneurons in RLS. © 2007 Movement Disorder Society
Scaglione C., Vetrugno R., Plazzi G., Rizzo G., Provini F., Montagna P., et al. (2008). Group I nonreciprocal inhibition in primary restless legs sindrome. MOVEMENT DISORDERS, 23(1), 96-100.
Group I nonreciprocal inhibition in primary restless legs sindrome.
SCAGLIONE, CESA LORELLA MARIA;VETRUGNO, ROBERTO;PLAZZI, GIUSEPPE;RIZZO, GIOVANNI;PROVINI, FEDERICA;MONTAGNA, PASQUALE;MARTINELLI, PAOLO
2008
Abstract
Abstract: Electrophysiological investigations of restless legs syndrome (RLS) have found spinal circuits impinging on motoneurones. We evaluated the H reflex threshold, latency, the Hmax/Mmax ratio, and the short latency autogenic inhibition in 7 patients with RLS and 10 age-matched controls by testing the excitability changes in soleus H reflex Ib interneuron function. A significant reduction in Ib inhibition at 4 (P 0.043), 5 (P 0.007), and 6 ms (P 0.001) of H reflex conditioning interstimulus interval was found in RLS patients. Data support the hypothesis that altered group I nonreciprocal inhibition is implicated in enhancing the spinal circuitry excitability of RLS, and are consistent with the view of an abnormal supraspinal drive to spinal interneurons in RLS. © 2007 Movement Disorder SocietyI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
