In this work we report the stimulation of astrocytic calcium signalling using an organic cell sensing and stimulating transistor (O-CST). We demonstrate that astroglial cells can adhere and proliferate on these devices giving us the possibility to stimulate bioelectrical activity in this type of cells. By the use of a microfluorimetric calcium imaging approach we show that our device is able to evoke an increase in intracellular calcium levels. This research opens a new path in the study of glial cells and their bioelectrical activity.
Ana Isabel Borrachero, C., Bonetti, S., Karges, S., Pistone, A., Quiroga, S.D., Natali, M., et al. (2015). An organic transistor architecture for stimulation of calcium signalling in primary rat cortical astrocytes. Institute of Electrical and Electronics Engineers Inc. [10.1109/NANO.2015.7388936].
An organic transistor architecture for stimulation of calcium signalling in primary rat cortical astrocytes
BORRACHERO CONEJO, ANA ISABEL;KARGES, SASKIA KATHARINA;Quiroga, Santiago D.;Caprini, Marco;
2015
Abstract
In this work we report the stimulation of astrocytic calcium signalling using an organic cell sensing and stimulating transistor (O-CST). We demonstrate that astroglial cells can adhere and proliferate on these devices giving us the possibility to stimulate bioelectrical activity in this type of cells. By the use of a microfluorimetric calcium imaging approach we show that our device is able to evoke an increase in intracellular calcium levels. This research opens a new path in the study of glial cells and their bioelectrical activity.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
