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EnglishTc-DPD (Tc-3,3-diphosphono-1,2-propanodicarboxylic acid) has a high affinity for transthyretin (TTR)-infiltrated myocardium, allowing a differential diagnosis with light chain cardiac amyloidosis and other nonamyloidotic cardiomyopathies with a hypertrophic phenotype, in which myocardial tracer uptake is low or absent. Myocardial bone tracer uptake in the rarer forms of amyloidosis (eg, apolipoprotein-related) has been rarely studied. We present 4 cases of cardiac amyloidosis that underwent Tc-DPD scintigraphy; myocardial DPD uptake was present in patients with ATTR, wtTTR and apolipoprotein AI and negative in cases with AL and apolipoprotein AII-related disease.
| Titolo: | Etiology of amyloidosis determines myocardial 99mTc-DPD uptake in amyloidotic cardiomyopathy |
| Autore/i: | LONGHI, SIMONE; BONFIGLIOLI, RACHELE; Obici, Laura; GAGLIARDI, CHRISTIAN; MILANDRI, AGNESE; LORENZINI, MASSIMILIANO; GUIDALOTTI, PIER LUIGI; Merlini, Giampaolo; RAPEZZI, CLAUDIO |
| Autore/i Unibo: | |
| Anno: | 2015 |
| Rivista: | |
| Digital Object Identifier (DOI): | 10.1097/RLU.0000000000000741 |
| Abstract: | Tc-DPD (Tc-3,3-diphosphono-1,2-propanodicarboxylic acid) has a high affinity for transthyretin (TTR)-infiltrated myocardium, allowing a differential diagnosis with light chain cardiac amyloidosis and other nonamyloidotic cardiomyopathies with a hypertrophic phenotype, in which myocardial tracer uptake is low or absent. Myocardial bone tracer uptake in the rarer forms of amyloidosis (eg, apolipoprotein-related) has been rarely studied. We present 4 cases of cardiac amyloidosis that underwent Tc-DPD scintigraphy; myocardial DPD uptake was present in patients with ATTR, wtTTR and apolipoprotein AI and negative in cases with AL and apolipoprotein AII-related disease. |
| Data stato definitivo: | 2016-11-10T15:00:22Z |
| Appare nelle tipologie: | 1.01 Articolo in rivista |
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