Background: The effectiveness of coronary radiation therapy for the treatment of in-stent restenosis (ISR) has been established in several randomized clinical trials. The efficacy of this treatment in the general population is less well established. Methods and materials: We report our experience in 118 consecutive patients with nonselected high-risk ISR who had undergone successful percutaneous coronary intervention and brachytherapy with 32P h-irradiation and who were prospectively enrolled in a quantitative angiographic and clinical follow-up protocol at 7 months after the index procedure. The aim of this study was to investigate the independent predictor of angiographic restenosis after 32P brachytherapy treatment. Results: Of the patients, 28.8% were diabetics. The mean lesion and mean radiated lengths were, respectively, 30.1F17.2 and 43.8F16.9 mm. The ISR pattern was diffuse in 96% of the treated lesions; in particular, 22.1% presented an occlusive pattern and 37.1% a proliferative pattern. At follow-up angiographic, restenosis and major adverse cardiac events (MACE) rates were, respectively, 20.8% and 29.6%. The univariate predictors of angiographic restenosis were procedural geographic miss, pattern IV ISR, manual pullback maneuver of the radiation source, preprocedural lesion percentage stenosis and preprocedural lesion MLD. At logistic regression analysis, only geographic miss and pattern IV ISR were independent predictors of post intracoronary radiation therapy (IRT) angiographic restenosis. Conclusion: These data indicate that 7-month angiographic restenosis after 32P IRT in complex patients with ISR is not a frequent event and is predicted mainly by an occlusive lesion at baseline and by procedural geographical miss.

Ortolani, P., Marzocchi, A., Aquilina, M., Gaiba, W., Bunkheila, F., Neri, S., et al. (2004). Predictors of 32P h brachytherapy failure in patients with high-risk in-stent restenosis. CARDIOVASCULAR RADIATION MEDICINE, 5(2), 77-83 [10.1016/j.carrad.2004.06.005].

Predictors of 32P h brachytherapy failure in patients with high-risk in-stent restenosis

TAGLIERI, NEVIO;BACCHI REGGIANI, MARIA LETIZIA;ORTOLANI, PAOLO;MARZOCCHI, ANTONIO;AQUILINA, MATTEO;GAIBA, WILLIAM;BUNKHEILA, FEISAL;NERI, STEFANO;BARBIERI, ENZA;BRANZI, ANGELO
2004

Abstract

Background: The effectiveness of coronary radiation therapy for the treatment of in-stent restenosis (ISR) has been established in several randomized clinical trials. The efficacy of this treatment in the general population is less well established. Methods and materials: We report our experience in 118 consecutive patients with nonselected high-risk ISR who had undergone successful percutaneous coronary intervention and brachytherapy with 32P h-irradiation and who were prospectively enrolled in a quantitative angiographic and clinical follow-up protocol at 7 months after the index procedure. The aim of this study was to investigate the independent predictor of angiographic restenosis after 32P brachytherapy treatment. Results: Of the patients, 28.8% were diabetics. The mean lesion and mean radiated lengths were, respectively, 30.1F17.2 and 43.8F16.9 mm. The ISR pattern was diffuse in 96% of the treated lesions; in particular, 22.1% presented an occlusive pattern and 37.1% a proliferative pattern. At follow-up angiographic, restenosis and major adverse cardiac events (MACE) rates were, respectively, 20.8% and 29.6%. The univariate predictors of angiographic restenosis were procedural geographic miss, pattern IV ISR, manual pullback maneuver of the radiation source, preprocedural lesion percentage stenosis and preprocedural lesion MLD. At logistic regression analysis, only geographic miss and pattern IV ISR were independent predictors of post intracoronary radiation therapy (IRT) angiographic restenosis. Conclusion: These data indicate that 7-month angiographic restenosis after 32P IRT in complex patients with ISR is not a frequent event and is predicted mainly by an occlusive lesion at baseline and by procedural geographical miss.
2004
Ortolani, P., Marzocchi, A., Aquilina, M., Gaiba, W., Bunkheila, F., Neri, S., et al. (2004). Predictors of 32P h brachytherapy failure in patients with high-risk in-stent restenosis. CARDIOVASCULAR RADIATION MEDICINE, 5(2), 77-83 [10.1016/j.carrad.2004.06.005].
Ortolani, Paolo; Marzocchi, Antonio; Aquilina, Matteo; Gaiba, William; Bunkheila, Feisal; Neri, Stefano; Lombardo, Enzo; Marrozzini, Cinzia; Pini, Ste...espandi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/565493
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