Leveraging the anion binding properties of thioureas, we show that the activity of known well-performing chiral catalysts can be reduced by coordinating anions (e.g. chloride) and restored by anion metatheses. Three benchmark enantioselective transformations were successfully studied, demonstrating the reversibility of the activation/deactivation processes.
Reversible modulation of the activity of thiourea catalysts with anions: A simple approach to switchable asymmetric catalysis / Foli, Giacomo; D'Elia, Cecilia Sasso; Fochi, Mariafrancesca; Bernardi, Luca. - In: RSC ADVANCES. - ISSN 2046-2069. - STAMPA. - 6:71(2016), pp. 66490-66494. [10.1039/c6ra12732k]
Reversible modulation of the activity of thiourea catalysts with anions: A simple approach to switchable asymmetric catalysis
FOLI, GIACOMO;FOCHI, MARIAFRANCESCA;BERNARDI, LUCA
2016
Abstract
Leveraging the anion binding properties of thioureas, we show that the activity of known well-performing chiral catalysts can be reduced by coordinating anions (e.g. chloride) and restored by anion metatheses. Three benchmark enantioselective transformations were successfully studied, demonstrating the reversibility of the activation/deactivation processes.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
