Pharmaceutically active compounds (PhACs) are common contaminants found in surface and groundwaters, often due to their inefficient removal from wastewater treatment plants. One way in which these compounds can be removed is via aerobic cometabolism, a process that involves oxygenases produced by microorganisms. Limited work has been done examining the efficacy of cometabolism in the removal of PhACs. Therefore, the aim of this work was to investigate the use of an alkane (pentane) in the aerobic cometabolic transformations of paracetamol, ibuprofen, naproxen, diclofenac, and nimesulide. Both paracetamol and ibuprofen (single aromatic compounds) were readily transformed, with net specific biodegradation rates equal to 1.6 and 3.2 μmol/gcell/day, respectively. Conversely, the two aromatic ring PhACs showed slower (naproxen and nimesulide) or no transformation (diclofenac). In addition, four of the tested PhACs (ibuprofen, paracetamol, naproxen and nimesulide) did not inhibit pentane uptake.

Cometabolic Degradation of Anti-Inflammatory and Analgesic Pharmaceuticals by a Pentane Enrichment Culture / Bragança, I.; Danko, A.S.; Pacheco, J.; Frascari, D.; Delerue-Matos, C.; Domingues, V.F. - In: WATER AIR AND SOIL POLLUTION. - ISSN 0049-6979. - STAMPA. - 227:7(2016), pp. 227.227-227.-. [10.1007/s11270-016-2933-9]

Cometabolic Degradation of Anti-Inflammatory and Analgesic Pharmaceuticals by a Pentane Enrichment Culture

FRASCARI, DARIO;
2016

Abstract

Pharmaceutically active compounds (PhACs) are common contaminants found in surface and groundwaters, often due to their inefficient removal from wastewater treatment plants. One way in which these compounds can be removed is via aerobic cometabolism, a process that involves oxygenases produced by microorganisms. Limited work has been done examining the efficacy of cometabolism in the removal of PhACs. Therefore, the aim of this work was to investigate the use of an alkane (pentane) in the aerobic cometabolic transformations of paracetamol, ibuprofen, naproxen, diclofenac, and nimesulide. Both paracetamol and ibuprofen (single aromatic compounds) were readily transformed, with net specific biodegradation rates equal to 1.6 and 3.2 μmol/gcell/day, respectively. Conversely, the two aromatic ring PhACs showed slower (naproxen and nimesulide) or no transformation (diclofenac). In addition, four of the tested PhACs (ibuprofen, paracetamol, naproxen and nimesulide) did not inhibit pentane uptake.
2016
Cometabolic Degradation of Anti-Inflammatory and Analgesic Pharmaceuticals by a Pentane Enrichment Culture / Bragança, I.; Danko, A.S.; Pacheco, J.; Frascari, D.; Delerue-Matos, C.; Domingues, V.F. - In: WATER AIR AND SOIL POLLUTION. - ISSN 0049-6979. - STAMPA. - 227:7(2016), pp. 227.227-227.-. [10.1007/s11270-016-2933-9]
Bragança, I.; Danko, A.S.; Pacheco, J.; Frascari, D.; Delerue-Matos, C.; Domingues, V.F
File in questo prodotto:
Eventuali allegati, non sono esposti

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/562793
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 8
  • ???jsp.display-item.citation.isi??? 7
social impact